Auhtors: Wu T, Wu X, Wang HY, Chen L PMID: 30999966 PMCID: PMC6471962 DOI: 10.1186/s40880-019-0365-9 Abstract Tumor immune microenvironment is closely related to tumor initiation, prognosis, and response to immunotherapy. The immune landscapes, number of infiltrating immune cells, and the localization of lymphocytes in the tumor vary in across different types of tumors. The immune [...]

Auhtors: Kim SR, Kim K, Lee SA, Kwon SO, Lee JK, Keum N, Park SM PMID: 30979076 PMCID: PMC6520977 DOI: 10.3390/nu11040826 Abstract Whether the risk of gastric cancer varies by the types of meat consumption still remains disputable. The purpose of this meta-analysis was to identify the exact associations that red, processed, and white meat [...]

Auhtors: D'Errico G, Alonso-Nocelo M, Vallespinos M, Hermann PC, Alcalá S, García CP, et al. PMID: 30936462 DOI: 10.1038/s41388-019-0803-9 Abstract Pancreatic ductal adenocarcinoma (PDAC) is an inherently chemoresistant tumor. Chemotherapy leads to apoptosis of cancer cells, and in previous studies we have shown that tumor-associated macrophage (TAM) infiltration increases following chemotherapy in PDAC. Since one [...]

Auhtors: Yan L, Sundaram S, Mehus AA, Picklo MJ PMID: 30952713 DOI: 10.21873/anticanres.13280 Abstract Background/aim: Obesity is a risk factor for cancer. Disruption of the daily feeding and fasting rhythm can contribute to obesity. This study tested the hypothesis that time-restricted feeding (TRF) attenuates obesity-enhanced metastasis. Materials and methods: In a spontaneous metastasis model of [...]

Auhtors: Cassetta L, Fragkogianni S, Sims AH, Swierczak A, Forrester LM, Zhang H, et al. PMID: 30930117 PMCID: PMC6472943 DOI: 10.1016/j.ccell.2019.02.009 Abstract The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human cancer are poorly understood. Here, we show that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and [...]

Auhtors: Tseng CH PMID: 30896668 PMCID: PMC6709307 DOI: 10.1097/MD.0000000000014955 Abstract Background: The relationship between metformin use and the risk of prostate cancer is still inconclusive. Therefore, we performed a systematic review and meta-analysis of all eligible cohort studies to evaluate a potential association of metformin use with prostate cancer risk. Methods: A comprehensive literature search [...]

Auhtors: Sissung TM, Schmidt KT, Figg WD DOI:https://doi.org/10.1016/S1470-2045(19)30003-8 Abstract Insulin is responsible for cellular glucose uptake and mitogenic signalling cascades in cancer cells,1 and can promote cell proliferation, survival, invasiveness, angiogenesis, immunomodulation, and chemoresistance.1–3 Why, then, would some medical practitioners claim that the use of insulin and glucose can improve the outcomes of patients with [...]

Auhtors: Li C, Wang Q, Shen S, Wei X, Li G PMID: 30653763 PMCID: PMC6590488 DOI: 10.1002/ptr.6273 Abstract Tumor metastasis is still the leading cause of melanoma mortality. Luteolin, a natural flavonoid, is found in fruits, vegetables, and medicinal herbs. The pharmacological action and mechanism of luteolin on the metastasis of melanoma remain elusive. In [...]

Auhtors: De Santi M, Baldelli G, Diotallevi A, Galluzzi L, Schiavano GF, Brandi G PMID: 30635619 PMCID: PMC6329809 DOI: 10.1038/s41598-018-37247-6 Abstract Autophagy is a cellular mechanism by which cells degrade intracellular components in lysosomes, maintaining cellular homeostasis. It has been hypothesized that autophagy could have a role in cancer prevention through the elimination of damaged [...]

Auhtors: Miyata Y, Shida Y, Hakariya T, Sakai H PMID: 30621039 PMCID: PMC6337309 DOI: 10.3390/molecules24010193 Abstract Prostate cancer is the most common cancer among men. Green tea consumption is reported to play an important role in the prevention of carcinogenesis in many types of malignancies, including prostate cancer; however, epidemiological studies show conflicting results regarding [...]