Auhtors: Choi YS, Cho HJ, Jung HJ PMID: 36039737 PMCID: PMC9437372 DOI: 10.4196/kjpp.2022.26.5.367 Abstract Gastric cancer stem cells (GCSCs) are a major cause of radioresistance and chemoresistance in gastric cancer (GC). Therefore, targeting GCSCs is regarded as a powerful strategy for the effective treatment of GC. Atorvastatin is a widely prescribed cholesterol-lowering drug that inhibits [...]

Auhtors: Zhao Z, Zeng J, Guo Q, Pu K, Yang Y, Chen N, et al. PMID: 34869024 PMCID: PMC8634032 DOI: 10.3389/fonc.2021.775418 Abstract Background: Cancer stem cells (CSCs) are able to survive after cancer therapies, resulting in tumor progression and recurrence, as is seen in colorectal cancer. Therapies targeting CSCs are regarded as novel and promising [...]

Auhtors: Fong D, Christensen CT, Chan MM PMID: 33563159 DOI: 10.2174/1574892816666210208232251 Abstract Background: Cancer is a multistep process involving genetic and epigenetic changes in the somatic genome. Genetic mutations as well as environmental factors lead to the initiation, promotion, and progression of cancer. Metastasis allows cancer cells to spread via circulatory and lymphatic systems; secondary [...]

Auhtors: Dionisio MR, Vieira AF, Carvalho R, Conde I, Oliveira M, Gomes M, et al. PMID: 33182375 PMCID: PMC7695320 DOI: 10.3390/cells9112442 Abstract Brain metastases remain an unmet clinical need in breast oncology, being frequently found in HER2-overexpressing and triple-negative carcinomas. These tumors were reported to be highly cancer stem-like cell-enriched, suggesting that brain metastases probably [...]

Auhtors: El-Benhawy SA, El-Sheredy HG, Ghanem HB, El-Soud AAA doi: https://doi.org/10.2217/bmt-2020-0007 Abstract Aim: Our objective was to investigate the effect of ionizing radiation (IR) and berberine on the expression of stem cell markers OCT4 and SOX2. Materials & methods: The study involved the following groups: Group I: MCF-7 spheroids as untreated control; Group II: MCF-7 [...]

Auhtors: Gorodetska I, Kozeretska I, Dubrovska A PMID: 31205572 PMCID: PMC6548160 DOI: 10.7150/jca.30410 Abstract Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations regulating genome integrity, cell division and death. The integrity of cellular genome is closely controlled by the mechanisms of DNA damage signaling and DNA repair. The association of breast cancer [...]

Auhtors: Dominguez-Gomez G, Chavez-Blanco A, Medina-Franco JL, Saldivar-Gonzalez F, Flores-Torrontegui Y, Juarez M, et al. PMID: 29257278 DOI: 10.3892/mmr.2017.8231 Abstract The aim of the present study was to demonstrate that ivermectin preferentially inhibited cancer stem‑like cells (CSC) in breast cancer cells and downregulated the expression of 'stemness' genes. Computational searching of DrugBank, a database of [...]

Auhtors: Singh VK, Saini A, Chandra R PMID: 28785557 PMCID: PMC5520001 DOI: 10.3389/fmolb.2017.00052 Abstract Cancer stem cells (CSCs) are believed to exhibit distinctive self-renewal, proliferation, and differentiation capabilities, and thus play a significant role in various aspects of cancer. CSCs have significant impacts on the progression of tumors, drug resistance, recurrence and metastasis in different [...]

Auhtors: Zhang L, Xu L, Zhang F, Vlashi E PMID: 27753527 PMCID: PMC5405729 DOI: 10.1080/15384101.2016.1241929 Abstract Experimental evidence suggest that breast tumors originate from breast cancer stem cells (BCSCs), and that mitochondrial biogenesis is essential for the anchorage-independent clonal expansion and survival of CSCs, thus rendering mitochondria a significant target for novel treatment approaches. One [...]

Auhtors: Huang Z, Wu T, Liu AY, Ouyang G PMID: 26474460 PMCID: PMC4741845 DOI: 10.18632/oncotarget.6098 Abstract Tumor cells actively contribute to constructing their own microenvironment during tumorigenesis and tumor progression. The tumor microenvironment contains multiple types of stromal cells that work together with the extracellular matrix and local and systemic factors to coordinately contribute to [...]