Authors: Zhao Y, Jia M, Chen W, Liu Z PMID: 35218914 DOI: 10.1016/j.freeradbiomed.2022.02.021 Abstract Intermittent fasting (IF) has been studied for its effects on lifespan and the prevention or delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria participate in key metabolic pathways and play important roles in maintaining intracellular signaling networks that [...]

Auhtors: Vasim I, Majeed CN, DeBoer MD PMID: 35276989 PMCID: PMC8839325 DOI: 10.3390/nu14030631 Abstract Given the ongoing strain that the obesity epidemic has placed on public health outcomes, new and effective approaches to weight control are needed. One approach to improving weight and metabolic outcomes is intermittent fasting, which consists of multiple different timing schedules [...]

Auhtors: Das M, Ellies LG, Kumar D, Sauceda C, Oberg A, Gross E, et al. PMID: 33495474 PMCID: PMC7835248 DOI: 10.1038/s41467-020-20743-7 Abstract Accumulating evidence indicates that obesity with its associated metabolic dysregulation, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Caloric restriction can ameliorate the [...]

Authors: Hannan A, Rahman A, Rahman S, Sohag AA, Dash R, Uddin J. PMID: 32659267 PMCID: PMC7351063 DOI: 10.1016/j.imlet.2020.07.001 Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative pathogen of deadly Coronavirus disease-19 (COVID-19) pandemic, which emerged as a major threat to public health across the world. Although there is no clear gender or [...]

Auhtors: de Cabo R, Mattson MP. PMID: 31881139 DOI: 10.1056/NEJMra1905136 Abstract Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity. Keywords: intermittent fasting, health, [...]

Authors: deCabo R, Mattson MP PMID: 31881139 DOI: 10.1056/NEJMra1905136 Abstract Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity. Keywords: fasting, intermittent fasting, health [...]

Auhtors: Sundaram S, Yan L PMID: 31188781 PMCID: PMC6594823 DOI: 10.18632/aging.102021 Abstract Aging increases the risk of cancer partly through alterations in the tissue microenvironment. Time-restricted feeding (TRF) is being proposed as an effective strategy to delay biological aging. In the present studies, we assessed the effect of long-term exposure to TRF on the emergence [...]

Auhtors: Yan L, Sundaram S, Mehus AA, Picklo MJ PMID: 30952713 DOI: 10.21873/anticanres.13280 Abstract Background/aim: Obesity is a risk factor for cancer. Disruption of the daily feeding and fasting rhythm can contribute to obesity. This study tested the hypothesis that time-restricted feeding (TRF) attenuates obesity-enhanced metastasis. Materials and methods: In a spontaneous metastasis model of [...]

Auhtors: Antures F, Erustes AG, Costa AJ, Nascimento AC, Bincoletto C, Ureshino RP, Smali SS PMID: 30540126 PMCID: PMC6257056 DOI: 10.6061/clinics/2018/e814s Abstract Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to [...]

Auhtors: Sundaram S, Yan L PMID: 30442235 DOI: 10.1016/j.nutres.2018.07.014 Abstract Erratic eating behavior disrupts the daily feeding and fasting pattern and leads to metabolic dysfunction and chronic diseases including cancer. In the present study, we tested the hypothesis that time-restricted feeding of a high-fat diet (HFD) to the dark phase does not enhance mammary tumorigenesis [...]