Authors: Al Sulaiman K, Aljuhani O, Al Dossari M, Alshahrani A, Alharbi A PMID: 34193235 PMCID: PMC8242279 DOI: 10.1186/s13054-021-03648-9 Abstract Background: Thiamine is a precursor of the essential coenzyme thiamine pyrophosphate required for glucose metabolism; it improves the immune system function and has shown to reduce the risk of several diseases. The role of thiamine [...]

Authors: Vatsalya V, Li F, Frimodig J, Gala KS, Srivastava S, Kong M PMID: 32869036 PMCID: PMC7457607 DOI: 10.1101/2020.08.23.20177501 Abstract Introduction Emerging infectious diseases, especially the coronavirus disease identified in 2019 (COVID-19), can be complicated by a severe exacerbation in the Th17 cell-mediated IL-17 proinflammatory immune storm. This enhanced immune response plays a major role [...]

Authors: Iglesias J, Vassallo AV, Patel V, Sullivan JB, Cavanaugh J, Elbaga Y PMID: 32194058 DOI: 10.1016/j.chest.2020.02.049 Abstract Background: Sepsis is a major public health burden resulting in 25% to 30% in-hospital mortality and accounting for over 20 billion dollars of US hospital costs. Research question: Does hydrocortisone, ascorbic acid, thiamine (HAT) therapy improve clinical [...]

Authors: Moskowitz A, Donnino MW PMID: 32148929 PMCID: PMC7024754 DOI: 10.21037/jtd.2019.12.82 Abstract Thiamine (vitamin B1) is a water-soluble vitamin essential for human health. Thiamine deficiency is causal and/or contributory in a number of debilitating diseases including beri-beri, the Wernicke-Korsakoff syndrome, optic neuropathy, and others. While thiamine deficiency is relatively rare in developed nations as a [...]

Auhtors: Marik PE PMID: 30441816 PMCID: PMC6265973 DOI: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, [...]

Authors: Marik PE PMID: 30441816 doi: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid [...]

Authors: Marik PE PMID: 30312231 DOI: 10.1097/CCM.0000000000003336 Keywords: delirium, sepsis, septic shock, thiamine, Wernicke’s Source: https://journals.lww.com/ccmjournal/citation/2018/11000/thiamine__an_essential_component_of_the_metabolic.23.aspx Archive: https://archive.ph/z98Jx

Authors: Woolum JA, Abner EL, Kelly A, Thompson Bastin ML, Morris PE, Flannery AH. PMID: 30028362 DOI: 10.1097/CCM.0000000000003311 Abstract Objectives: Mounting evidence has shown that critically ill patients are commonly thiamine deficient. We sought to test the hypothesis that critically ill patients with septic shock exposed to thiamine would demonstrate improved lactate clearance and more [...]

Authors: Menezes RR, Godin AM, Rodrigues FF, Coura GM, Melo IS, Brito AM PMID: 28958614 DOI: 10.1016/j.pharep.2017.04.011 Abstract Background: The effects induced by thiamine and riboflavin, isolated or in association with corticosteroids, in models of chronic inflammation are not known. Thus, we evaluated the effect induced by these B vitamins, isolated or in association with [...]

Authors: Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J PMID: 27940189 DOI: 10.1016/j.chest.2016.11.036 Abstract Background: The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. Methods: In this retrospective before-after clinical study, we compared the outcome and clinical course of [...]