Auhtors: Morishita H, Mizushima N PMID: 31283377 DOI: 10.1146/annurev-cellbio-100818-125300 Abstract Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular [...]

Auhtors: Agrawal S, Vamadevan P, Mazibuko N, Bannister R, Swery R, Wilson S PMID: 31316378 PMCID: PMC6610246 DOI: 10.3389/fphar.2019.00681 Abstract In oncology, preclinical and early clinical data increasingly support the use of a number of candidate "non-cancer" drugs in an off-label setting against multiple tumor types. In particular, metabolically targeted drugs show promise as adjuvant [...]

Auhtors: An KY, Morielli AR, Kang DW, Friedenreich CM, McKenzie DC, Gelmon K, et al. PMID: 31173341 DOI: 10.1002/ijc.32493 Abstract The Combined Aerobic and Resistance Exercise (CARE) Trial compared different types and doses of exercise performed during breast cancer chemotherapy. Here, we report the longer-term follow-up of patient-reported outcomes, health-related fitness and exercise behavior at [...]

Auhtors: Nayeem M, Chauhan K Abstract The aim of the review is to evaluate the oxidative potentials of Wheat, Sorghum grass, and Barley grass juices and its Anti diabetic activity. Diabetes mellitus is a major disease over worldwide many deaths every year. Now we have chosen the essential grasses juices which plays an important role [...]

Auhtors: Ohue Y, Nishikawa H PMID: 31102428 PMCID: PMC6609813 DOI: 10.1111/cas.14069 Abstract Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self- and nonself-antigens to maintain immune homeostasis. In tumor immunity, Treg cells are involved in tumor development and progression by inhibiting antitumor immunity. There are several Treg cell immune suppressive mechanisms: inhibition of costimulatory [...]

Auhtors: Sundaram S, Yan L PMID: 31188781 PMCID: PMC6594823 DOI: 10.18632/aging.102021 Abstract Aging increases the risk of cancer partly through alterations in the tissue microenvironment. Time-restricted feeding (TRF) is being proposed as an effective strategy to delay biological aging. In the present studies, we assessed the effect of long-term exposure to TRF on the emergence [...]

Auhtors: Santos HO, de Moraes WM, da Silva GA, restes J, Schoenfeld BJ PMID: 31221273 DOI: 10.1016/j.clnesp.2019.05.008 Abstract Vinegar intake is considered a food item that improves blood glucose in humans. This review aimed to discuss studies that investigated the impact of vinegar intake on the glycemic profile in humans and the putative mechanistic cellular [...]

Auhtors: Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, et al. Abstract Glioblastoma (GBM) is an aggressive primary human brain tumour that has resisted effective therapy for decades. Although glucose and glutamine are the major fuels that drive GBM growth and invasion, few studies have targeted these fuels for therapeutic management. [...]

Auhtors: Huang W, Sundquist J, Sundquist K, Ji J PMID: 31103628 DOI: 10.1053/j.gastro.2019.05.012 Abstract Background & aims: Phosphodiesterase 5 (PDE5) inhibitors have been proposed to have chemopreventative effects on colorectal cancer (CRC), although data are needed from population-based studies. We performed a nationwide cohort study to investigate the association between the use of PDE5 inhibitors [...]

Auhtors: Gorodetska I, Kozeretska I, Dubrovska A PMID: 31205572 PMCID: PMC6548160 DOI: 10.7150/jca.30410 Abstract Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations regulating genome integrity, cell division and death. The integrity of cellular genome is closely controlled by the mechanisms of DNA damage signaling and DNA repair. The association of breast cancer [...]