Auhtors: Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, et al. PMID: 30415629 PMCID: PMC6425757 DOI: 10.1056/NEJMoa1809944 Abstract Background: It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. Methods: We conducted a nationwide, randomized, placebo-controlled trial, with [...]

Auhtors: Sung SJ, Kim H-K, Hong Y-K, Joe YA PMID: 30642153 PMCID: PMC6319545 DOI: 10.4062/biomolther.2018.222 Abstract Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy. However, the definite anti-angiogenic mechanism of MBZ remains unclear. In this [...]

Auhtors: Reddy P, Edwards LR PMID: 28471760 DOI: 10.1097/MJT.0000000000000538 Abstract Background: Vitamin D and magnesium (Mg) are some of the most studied topics in medicine with enormous implications for human health and disease. Majority of the adults are deficient in both vitamin D and magnesium but continue to go unrecognized by many health care professionals. [...]

Auhtors: Chandrasekaran B, Pal D, Kolluru V, Tyagi A, Baby B, Dahiya NR, et al. PMID: 30124785 PMCID: PMC6314334 DOI: 10.1093/carcin/bgy109 Abstract Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal and colon carcinogenesis remain unknown. We investigated the chemopreventive effect of WA on transgenic adenomatous polyposis coli (APCMin/+) mouse and chemically induced [...]

Auhtors: Chinopoulos C, Seyfried TN PMID: 30909720 PMCID: PMC6311572 DOI: 10.1177/1759091418818261 Abstract Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit mitochondrial abnormalities incompatible with energy production through oxidative phosphorylation (OxPhos). Under such conditions, the mitochondrial F0-F1 ATP synthase operates [...]

Auhtors: Wang W, Liu Y, Guo J, He H, Mi X, Chen C, et al. PMID: 30563983 PMCID: PMC6299090 DOI: 10.1038/s41389-018-0106-y Abstract Tumor-associated macrophages (TAMs), the main part of immune cells in tumor microenvironment (TME), play a potent role in promoting tumorigenesis through mechanisms such as stimulating angiogenesis, enhancing tumor migration and suppressing antitumor immunity. [...]

Auhtors: Su J, Li D, Chen Q, Li M, Su L, Luo T, et al. PMID: 30619178 PMCID: PMC6304348 DOI: 10.3389/fmicb.2018.03099 Abstract Increasing evidence highlights the cardinal role of gut microbiota in tumorigenesis and chemotherapy outcomes. Paclitaxel (PTX), although as a first-line chemotherapy reagent for breast cancer, still requires for improvement on its efficacy and [...]

Auhtors: Antures F, Erustes AG, Costa AJ, Nascimento AC, Bincoletto C, Ureshino RP, Smali SS PMID: 30540126 PMCID: PMC6257056 DOI: 10.6061/clinics/2018/e814s Abstract Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to [...]

Auhtors: Yang T, Qiao Y, Xiang S, Li W, Gan Y, Chen Y PMID: 30484859 DOI: 10.1002/ijc.31955 Abstract Epidemiological studies have explored the relationship between work stress and the risk of cancer, but it remains unclear on whether work stress could increase the risk of cancer, or by other factors such as smoking and physical [...]

Authors: Pantziarka P, Verbaanderd C, Sukhatme V, Rica C, I, Crispino S, Gyawali B, et al. PMID: 30679953 PMCID: PMC6345075 DOI: 10.3332/ecancer.2018.886 Abstract Repurposing is a drug development strategy that seeks to use existing medications for new indications. In oncology, there is an increased level of activity looking at the use of non-cancer drugs as [...]