Auhtors: Butti R, Gunasekaran VP, Kumar TVS, Banerjee P, Kundu GC PMID: 30529656 DOI: 10.1016/j.biocel.2018.12.001 Abstract Breast cancer remains to be a dreadful disease even with several advancements in radiation and chemotherapies, owing to the drug resistance and tumor relapse caused by breast cancer stem cells. Cancer stem cells are a minute population of cells [...]

Auhtors: Jin F, Xie T, Huang X, Zhao X PMID: 31070539 PMCID: PMC6319470 DOI: 10.1080/13880209.2018.1548627 Abstract Context: Berberine is used in traditional Chinese medicine for thousands of years with recent reports of its anticancer activity. Objective: To test antiangiogenic effects of berberine on human glioblastoma and clarify involvement of the VEGFR2/ERK pathway. Materials and methods: [...]

Auhtors: Advani SM, Advani PG, VonVille HM, Jafri SH PMID: 30482179 PMCID: PMC6260745 DOI: 10.1186/s12885-018-5080-4 Abstract Background: Cachexia is a multisystem syndrome characterized by weight loss, anorexia, loss of muscle mass, systemic inflammation, insulin resistance, and functional decline. Management of cachexia involves addressing multiple underlying biological mechanisms. Previous review on pharmacological management of cancer cachexia [...]

Auhtors: Chen Y, Tan F, Wei L, Li X, Lyu Z, Feng X, et al. PMID: 30463535 PMCID: PMC6249821 DOI: 10.1186/s12885-018-5025-y Abstract Background: The effect of sleep duration on cancer risk remains controversial. We aimed to quantify the available evidence on this relationship using categorical and dose-response meta-analyses. Methods: Population-based cohort studies and case-control studies [...]

Auhtors: Marik PE PMID: 30441816 PMCID: PMC6265973 DOI: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, [...]

Auhtors: Khadge S, Sharp JG, Mcguire TR, Thiele GM, Black P, Dirusso C, et al. PMID: 30447537 PMCID: PMC6322683 DOI: 10.1016/j.intimp.2018.10.026 Abstract Rodent and clinical studies have documented that myeloid cell infiltration of tumors is associated with poor outcomes, neutrophilia and lymphocytopenia. This contrasts with increased lymphocyte infiltration of tumors, which is correlated with improved [...]

Auhtors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 DOI: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]

Auhtors: Zhang Y, Fan Y, Huang S, Wang G, Han R, Lei F, et al. PMID: 30259603 PMCID: PMC6272120 DOI: 10.1111/cas.13808 Abstract Thymoquinone (TQ, 2-methyl-5-isopropyl-1,4-benzoquinone), a bioactive constituent extracted from the seeds of Nigella sativa, has been proved to exert anti-tumor efficiency in various cancers. Autophagy is a self-digestion phenomenon, and its role in tumor [...]

Auhtors: Vallianou NG, Stratigou T, Tsagarakis S PMID: 30342053 DOI: 10.1016/j.diabres.2018.10.008 Abstract Alterations in the diversity or structure of gut microbiota known as dysbiosis, may affect metabolic activities, resulting in metabolic disorders, such as obesity and diabetes. The development of more sophisticated methods, such as metagenomics sequencing, PCR-denaturing gradient gel electrophoresis, microarrays and fluorescence in [...]

Auhtors: Sharabi A, tsokos MG, Ding Y, Malek TR, Klatzmann D, Tsokos GC PMID: 30310234 DOI: 10.1038/nrd.2018.148 Abstract Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In patients with systemic or organ-specific autoimmune diseases or those receiving transplanted organs, Treg cells are compromised. Approaches to strengthen Treg cell function, either by expanding [...]