Auhtors: Liu Z, Peng Q, Li Y, Gao Y PMID: 30103844 PMCID: PMC6177506 DOI: 10.5483/BMBRep.2018.51.9.114 Abstract Cisplatin is one of the most effective chemotherapeutic drugs used in the treatment of HCC, but many patients will ultimately relapse with cisplatin-resistant disease. Used in combination with cisplatin, resveratrol has synergistic effect of increasing chemosensitivity of cisplatin in [...]

Auhtors: Awad RM, De Vlaeminck Y, Maebe J, Goyvaerts C, Breckpot K PMID: 30233579 PMCID: PMC6127274 DOI: 10.3389/fimmu.2018.01977 Abstract Tumor cells frequently produce soluble factors that favor myelopoiesis and recruitment of myeloid cells to the tumor microenvironment (TME). Consequently, the TME of many cancer types is characterized by high infiltration of monocytes, macrophages, dendritic cells [...]

Auhtors: Gaziano JM, Brotons C, Coppolecchia R, Cricelli C, Darius H, Gorelick PB, et al. PMID: 30158069 PMCID: PMC7255888 DOI: 10.1016/S0140-6736(18)31924-X Abstract Background: The use of aspirin in the primary prevention of cardiovascular events remains controversial. We aimed to assess the efficacy and safety of aspirin versus placebo in patients with a moderate estimated risk [...]

Auhtors: Sundaram S, Yan L PMID: 30442235 DOI: 10.1016/j.nutres.2018.07.014 Abstract Erratic eating behavior disrupts the daily feeding and fasting pattern and leads to metabolic dysfunction and chronic diseases including cancer. In the present study, we tested the hypothesis that time-restricted feeding of a high-fat diet (HFD) to the dark phase does not enhance mammary tumorigenesis [...]

Auhtors: Puar YR, Shanmugam MK, Fan L, Arfuso F, Sethi G, Tergaonkar V PMID: 30060453 PMCID: PMC6163404 DOI: 10.3390/biomedicines6030082 Abstract Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the regulation of a large number of genes that are involved in important physiological processes, including survival, inflammation, and immune responses. At the same [...]

Auhtors: Pan B, Ge L, Xun YQ, Chen YJ, Gao CY, Han X, et al. PMID: 30045740 PMCID: PMC6060544 DOI: 10.1186/s12966-018-0703-3 Abstract Introduction: Current international guidelines recommend aerobic, resistance, and combined exercises for the management of type 2 diabetes mellitus (T2DM). In our study, we conducted a network meta-analysis to assess the comparative impact of [...]

Auhtors: Scott JM, Zabor EC, Schwitzer E, Koelwyn GJ, Adams SC, Nilsen TS, et al. PMID: 29894274 PMCID: PMC6804903 DOI: 10.1200/JCO.2017.77.5809 Abstract Purpose To evaluate the effects of exercise therapy on cardiorespiratory fitness (CRF) in randomized controlled trials (RCTs) among patients with adult-onset cancer. Secondary objectives were to evaluate treatment effect modifiers, safety, and fidelity. [...]

Auhtors: Gyori D, Lim EL, Grant FM, Spensberger D, Roychoudhuri R, Shuttleworth SJ, et al. PMID: 29875321 PMCID: PMC6124419 DOI: 10.1172/jci.insight.120631 Abstract Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3+ regulatory T (Treg) cells promote tumor progression by limiting antitumor immunity. Here we [...]

Authors: Beljanski S Abstract A new breakthrough book, Winning the War on Cancer:The Epic Journey Towards a Natural Cure reveals the visionary discoveries of a French scientist whose suppressed research led to improvements in the prevention and treatment of cancer...naturally and without toxicity.This book is a "story within a story" as through its pages, Sylvie [...]

Auhtors: Kelly P, Williamson C, Niven AG, Hunter R, Mutrie N, Richards J PMID: 29858467 DOI: 10.1136/bjsports-2017-098827 Abstract Background/objectives: Walking has well-established positive relationships with, and effects on, physical health. In contrast, while poor mental health contributes substantially to global health burden, an overview of the benefits from walking has not previously been published. We [...]