Auhtors: Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, et al. PMID: 29657030 PMCID: PMC5932217 DOI: 10.1016/j.cmet.2018.03.002 Abstract Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated [...]

Auhtors: Blum A, Wang P, Zenklusen JC PMID: 29625059 DOI: 10.1016/j.cell.2018.03.059 Abstract This SnapShot provides a list of the tumor types characterized by The Cancer Genome Atlas (TCGA) program. Key findings shown are the most relevant discoveries described in each marker paper for the tumor type. Keywords: cancer, tumors Source: https://pubmed.ncbi.nlm.nih.gov/29625059/ Archive: https://archive.ph/REF1b [...]

Auhtors: Zhang P, Li H, Tan X, Chen L, Wang S PMID: 29618465 DOI: 10.1158/1055-9965.EPI-17-0936 Abstract Background: Preclinical data suggest that metformin may reduce breast cancer incidence and improve cancer prognosis. However, the current evidence in observational studies is inconclusive. A systematic review and meta-analysis was conducted to assess the effect of metformin on the [...]

Auhtors: Knochelmann HM, Dwyer CJ, Bailey SR, Amaya SM, Elston DM, Mazza-McCrann JM, Paulos CM PMID: 29563615 PMCID: PMC6068176 DOI: 10.1038/s41423-018-0004-4 Abstract The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent factor in regulating autoimmunity and cancer. Th17 cells are vital for host defense against pathogens but have also [...]

Auhtors: Carballo GB, Honorato JR, de Lopes GPF, Spohr TCLS PMID: 29558958 PMCID: PMC5861627 DOI: 10.1186/s12964-018-0220-7 Abstract Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio and chemo-resistance of several types of tumors. Most [...]

Auhtors: Taylor KW, Troester MA, Herring AH, Engel LS, Nichols HB, Sandler DP, Baird DD PMID: 29467107 PMCID: PMC6066348 DOI: 10.1289/EHP1480 Abstract Background: Many personal care products include chemicals that might act as endocrine disruptors and thus increase the risk of breast cancer. Objective: We examined the association between usage patterns of beauty, hair, and [...]

Auhtors: Fiolet T, Srour B, Sellem L, Kesse-Guyot E, Allès B, Méjean C, et al. PMID: 29444771 PMCID: PMC5811844 DOI: 10.1136/bmj.k322 Abstract Objective: To assess the prospective associations between consumption of ultra-processed food and risk of cancer. Design: Population based cohort study. Setting and participants: 104 980 participants aged at least 18 years (median age [...]

Auhtors: Ifland J, Marcus MT, Preuss HG Abstract Obesity and eating disorders have stubbornly refused to respond to treatment since the 1990’s. This book organizes the evidence for a possible answer, i.e., that the problem could be one of addiction to processed foods. In a Processed Food Addiction (PFA) model, concepts of abstinence, cue-avoidance, acceptance [...]

Auhtors: Baracos VE, Martin L, Korc M, Guttridge DC, Fearon KCH PMID: 29345251 DOI: 10.1038/nrdp.2017.105 Abstract Cancer-associated cachexia is a disorder characterized by loss of body weight with specific losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination of reduced food intake and metabolic changes, including elevated energy expenditure, excess [...]

Auhtors: Siddiqui FJ, Assam PN, de Souza NN, Sultana R, Dalan r, Chan ES PMID: 29756472 PMCID: PMC5954571 DOI: 10.1177/2156587217753004 Abstract Background: Renewed interest in vinegar as a glucose-lowering agent led to several small trials in the recent past. However, none of the trials could independently provide sufficient evidence. Objectives: Our review aimed to obtain [...]