Auhtors: Yu C, Li W-b, Liu J-b, Lu J-w, Feng J-f PMID: 29282893 PMCID: PMC5806108 DOI: 10.1002/cam4.1287 Abstract In eukaryotic cells, autophagy is a process associated with programmed cell death. During this process, cytoplasmic proteins and organelles are engulfed by double-membrane autophagosomes, which then fuse with lysosomes to form autolysosomes. These autolysosomes then degrade their [...]

Auhtors: Oberoi S, Robinson PD, Cataudella D, Culos-Reed SN, Davis H, Duong N, et al. PMID: 29458789 DOI: 10.1016/j.critrevonc.2017.12.011 Abstract Purpose: Objective was to determine whether physical activity reduces the severity of fatigue in patients with cancer or hematopoietic stem cell transplant (HSCT) recipients. Methods: We conducted a meta-analysis of randomized trials comparing physical activity [...]

Auhtors: Augustin K, Khabbush A, Williams S, Eaton S, Orford M, Cross JH, et al. PMID: 29263011 DOI: 10.1016/S1474-4422(17)30408-8 Abstract High-fat, low-carbohydrate diets, known as ketogenic diets, have been used as a non-pharmacological treatment for refractory epilepsy. A key mechanism of this treatment is thought to be the generation of ketones, which provide brain cells [...]

Auhtors: Dominguez-Gomez G, Chavez-Blanco A, Medina-Franco JL, Saldivar-Gonzalez F, Flores-Torrontegui Y, Juarez M, et al. PMID: 29257278 DOI: 10.3892/mmr.2017.8231 Abstract The aim of the present study was to demonstrate that ivermectin preferentially inhibited cancer stem‑like cells (CSC) in breast cancer cells and downregulated the expression of 'stemness' genes. Computational searching of DrugBank, a database of [...]

Auhtors: Mørch LS, Skovlund CW, Hannaford PC, Iversen L, Fielding S, Lidegaard Ø PMID: 29211679 DOI: 10.1056/NEJMoa1700732 Abstract Background: Little is known about whether contemporary hormonal contraception is associated with an increased risk of breast cancer. Methods: We assessed associations between the use of hormonal contraception and the risk of invasive breast cancer in a [...]

Auhtors: Na RS, Ma C, Liu QR, Wu LM, Zheng XL, Liu ZW PMID: 29434820 PMCID: PMC5776524 DOI: 10.3892/etm.2017.5602 Abstract The primarily metabolic abnormality in type 2 diabetes mellitus (T2DM) is the defect in gluconeogenesis and glucose uptake. Itraconazole (ITCZ) is a traditional azole drug with anti-fungal and anticancer properties. However, limited attention has been [...]

Auhtors: Ko JH, Sethi G, Um JY, Shanmugam MK, Arfuso F, Kumar AP, et al. PMID: 29194365 PMCID: PMC5751192 DOI: 10.3390/ijms18122589 Abstract Abstract: Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, including cancer. A significant amount of research, including preclinical, clinical, and epidemiological studies, [...]

Auhtors: Kitano Y, Okabe H, Yamashita YI, Nakagawa S, Saito Y, Umezaki N, et al. PMID: 29123259 PMCID: PMC5785749 DOI: 10.1038/bjc.2017.401 Abstract Background: Inflammation and immune characteristics of the tumour microenvironment have therapeutic significance. The aim of this study was to investigate the clinical impact on disease progression in human extrahepatic cholangiocarcinoma (ECC). Methods: A [...]

Auhtors: Maruvada P, Leone V, Kaplan LM, Chang EB PMID: 29120742 DOI: 10.1016/j.chom.2017.10.005 Abstract Mounting evidence indicates that the gut microbiome responds to diet, antibiotics, and other external stimuli with speed and high precision and in ways that impact a variety of metabolic conditions including obesity and non-alcoholic fatty liver disease. Despite a decade of [...]

Auhtors: Liu S, Chen S, Zeng J PMID: 29115550 DOI: 10.3892/mmr.2017.7970 Abstract Tumor progression can be affected by various cellular components of tumor cells and/or by tumor microenvironmental factors. The tumor microenvironment comprises a variety of nonmalignant stromal cells and inflammatory cytokines, which are pivotal in tumor promotion and progression. The transforming growth factor‑β (TGF‑β) [...]