Authors: Yoshihara T, Shimada K, Fukao K, Sai E, Matsumori R, Alshahi H PMID: 25925976 DOI: 10.1253/circj.CJ-14-0471 Abstract Background: Dietary intake of ω3 polyunsaturated fatty acids (ω3-PUFAs) reduces progression of atherosclerosis and prevents future cardiovascular events. Macrophages are key players in the pathogenesis of aortic aneurysm. The effects of ω3-PUFAs on abdominal aortic aneurysm [...]

Authors:Dancer RC, Parekh D, Lax S, D'Souza VD, Zheng S, Bassford CR et al. PMID: PMC4484044 DOI: 10.1136/thoraxjnl-2014-206680 Abstract Rationale: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory distress syndrome (ARDS). Causality of these [...]

Auhtors: Ruffell B, Coussens LM. PMID: 25858805 PMCID: PMC4400235 DOI: 10.1016/j.ccell.2015.02.015 Abstract How neoplastic cells respond to therapy is not solely dependent on the complexity of the genomic aberrations they harbor but is also regulated by numerous dynamic properties of the tumor microenvironment. Identifying and targeting critical pathways that improve therapeutic efficacy by bolstering anti-tumor [...]

Auhtors: Meidenbauer JJ, Mukherjee P, Seyfried TN Abstract Background Metabolic therapy using ketogenic diets (KD) is emerging as an alternative or complementary approach to the current standard of care for brain cancer management. This therapeutic strategy targets the aerobic fermentation of glucose (Warburg effect), which is the common metabolic malady of most cancers including brain [...]

Auhtors: Lahart IM, Metsios GS, Nevill AM, Carmichael AR PMID: 25752971 DOI: 10.3109/0284186X.2014.998275 Abstract Strong evidence exists supporting the effect of lack of physical activity on the risk of developing breast cancer. However, studies examining the effects of physical activity on breast cancer outcomes, including survival and prognosis have been inconclusive. Therefore, the aim of [...]

Auhtors: Zitvogel L, Galluzzi L, Viaud S, Vétizou M, Daillère R, Merad M, Kroemer G PMID: 25609166 PMCID: PMC4690201 DOI: 10.1126/scitranslmed.3010473 Abstract Changes in the interactions among the gut microbiota, intestinal epithelium, and host immune system are associated with many diseases, including cancer. We discuss how environmental factors infuence this cross-talk during oncogenesis and tumor [...]

Auhtors: Savage P PMID: 25605631 PMCID: PMC4308945 DOI: 10.1186/s12885-015-1006-6 Abstract Background: A select number of relatively rare metastatic malignancies comprising trophoblast tumours, the rare childhood cancers, germ cells tumours, leukemias and lymphomas have been routinely curable with chemotherapy for more than 30 years. However for the more common metastatic malignancies chemotherapy treatment frequently brings clinical [...]

Auhtors: Hirshkowitz M, Whiton K, Albert SM, Alessi C, Bruni O, DonCarlos L, et al. PMID: 29073412 DOI: 10.1016/j.sleh.2014.12.010 Abstract Objective: The objective was to conduct a scientifically rigorous update to the National Sleep Foundation's sleep duration recommendations. Methods: The National Sleep Foundation convened an 18-member multidisciplinary expert panel, representing 12 stakeholder organizations, to evaluate [...]

Auhtors: Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner SP, et al. PMID: 25470039 PMCID: PMC4465385 DOI: 10.1038/nature14034 Abstract Cytotoxic chemotherapy is effective in debulking tumour masses initially; however, in some patients tumours become progressively unresponsive after multiple treatment cycles. Previous studies have demonstrated that cancer stem cells (CSCs) are selectively enriched [...]

Authors: Serhan CN PMID: 24899309 PMCID: PMC4263681 doi: 10.1038/nature13479 Abstract Advances on mechanisms in resolution of acute inflammation uncovered a new genus of pro-resolving lipid mediators that include separate families of molecules: lipoxins, resolvins, protectins and maresins, collectively coined specialized pro-resolving mediators (SPM). Synthetic SPM possess potent bioactions when administered in vivo. In animal experiments, [...]