Authors: Langguth B PMID: 26261868 DOI: 10.1097/MOO.0000000000000185 Abstract Purpose of review: Tinnitus, the perception of sound in the absence of a corresponding external acoustic stimulus, is a highly prevalent and frequently severely impairing disorder with worldwide impact. In this article after a short overview about epidemiology and pathophysiology the currently available treatment options will be [...]

Auhtors: Condamine T, Mastio J, Gabrilovich DI PMID: 26337512 PMCID: PMC4661041 DOI: 10.1189/jlb.4RI0515-204R Abstract Myeloid-derived suppressor cells are a heterogeneous group of pathologically activated immature cells that play a major role in the negative regulation of the immune response in cancer, autoimmunity, many chronic infections, and inflammatory conditions, as well as in the regulation of [...]

Auhtors: Rebello CJ, Burton J, Heiman M, Greenway FL. PMID: 26424589 PMCID: PMC4656110 DOI: 10.1016/j.jdiacomp.2015.08.023 Abstract Objective: The objective of this study was to examine the effects of a gastrointestinal microbiome modulator (GIMM) containing inulin, β-glucan, blueberry anthocyanins, and blueberry polyphenols on metabolic parameters, fecal markers of gut microbiota, and satiety. Design and methods: [...]

Auhtors: Boursi B, Mamtani R, Haynes K, Yang YX PMID: 26338196 PMCID: PMC4663115 DOI: 10.1016/j.ejca.2015.08.015 Abstract Background: Bacterial dysbiosis was previously described in human malignancies. In a recent animal model, tumour susceptibility was transmitted using faecal transplantation. Our aim was to evaluate possible association between antibiotic exposure and cancer risk. Methods: We conducted nested case-control [...]

Abstract How on earth could an antidepressant drug drive someone to murder? In the past two columns RxISK has heard from two people who know they can. In The Man Who Thought He Was A Monster, Steindor Erlingsson shared his own story of being tormented with urges to stab his wife and young children while [...]

Schmitt B, Vicenzi M, Garrel C, Denis FM. PMID: 26262996 PMCID: PMC4536296 DOI: 10.1016/j.redox.2015.07.012 Abstract Glutathione (GSH) is critical to fight against oxidative stress. Its very low bioavailability limits the interest of a supplementation. The purpose of this study was to compare the bioavailability, the effect on oxidative stress markers and the safety of [...]

Authors: Akagawa M, Nakano M, Ikemoto K PMID: 26168402 DOI: 10.1080/09168451.2015.1062715 Abstract Pyrroloquinoline quinone (PQQ), an aromatic tricyclic o-quinone, was identified initially as a redox cofactor for bacterial dehydrogenases. Although PQQ is not biosynthesized in mammals, trace amounts of PQQ have been found in human and rat tissues because of its wide distribution in dietary [...]

Auhtors: Scoccianti C, Key TJ, Anderson AS, Armaroli P, Berrino F, Cecchini M, et al. PMID: 26116994 DOI: 10.1016/j.canep.2014.12.007 Abstract Breast cancer is the most frequent cancer in women, and incidence rates have been rising in European Union (EU) countries over recent decades due in part to a sharp decline in breastfeeding practices. Evidence for [...]

Auhtors: Ng K, Venook AP, Sato K, Yuan C, Hollis BW, Chang IW, et al. doi: https://doi.org/10.1200/jco.2015.33.15_suppl.3503 Abstract Background: Prospective epidemiologic data suggest that higher levels of 25-hydroxyvitamin D [25(OH)D] are associated with improved survival in patients with colorectal cancer, however the relationship between 25(OH)D and outcome in metastatic CRC (mCRC), specifically, is unknown. Methods: [...]

Auhtors: Shakya G, Balasubramanian S, Rajagopalan R PMID: 26109759 PMCID: PMC4461953 DOI: 10.4103/0973-1296.157715 Abstract Background: Deregs been implicated in the malignancy of cancer. Since many years investigation on the traditional herbs has been the focus to develop novel and effective drug for cancer remedies. Wheatgrass is a medicinal plant, used in folk medicine to cure [...]