Authors: Weng Z, Patel AB, Panagiotidou S, Theoharides TC PMID: 25498791 PMCID: PMC4388775 DOI: 10.1016/j.jaci.2014.10.032 Abstract Background: Mast cells (MCs) are hematopoietic cells that mature in tissues and are involved in allergy, immunity, and inflammation by secreting multiple mediators. The natural flavone luteolin has anti-inflammatory actions and inhibits human mast cells (MCs). Objective: We sought [...]

Authors: Cao J, Forrest CJ, Zhang X PMID: 25451075 PMCID: PMC7113785 DOI: 10.1016/j.antiviral.2014.11.010 Abstract With the recent emergence of Middle East Respiratory Syndrome coronavirus in humans and the outbreak of devastating porcine epidemic diarrhea coronavirus in swine, therapeutic intervention is urgently needed. However, anti-coronavirus drugs currently are not available. In an effort to assist rapid [...]

Auhtors: Pantziarka P, Bouche G, Meheus L, Sukhatme V, Sukhatme VP PMID: 25525463 PMCID: PMC4268104 DOI: 10.3332/ecancer.2014.485 Abstract Cimetidine, the first H2 receptor antagonist in widespread clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical and clinical studies for a number of different cancer types. These data are summarised [...]

Glucocorticosteroids (GCS) are used on a daily basis to reduce airway inflammation in asthma and chronic obstructive pulmonary disease (COPD). This treatment is usually escalated during acute disease exacerbations, events often associated with virus infections.

Authors: Thomas BJ, Porritt RA, Hertzog PJ, Bardin PG PMID: 25417801 PMCID: PMC5384105 DOI: 10.1038/srep07176 Abstract Glucocorticosteroids (GCS) are used on a daily basis to reduce airway inflammation in asthma and chronic obstructive pulmonary disease (COPD). This treatment is usually escalated during acute disease exacerbations, events often associated with virus infections. We examined the impact [...]

Auhtors: Larsen AR, Bai RY, Chung JH, Borodovsky A, Rudin CM, Riggins GJ, Bunz F PMID: 25376612 PMCID: PMC4297232 DOI: 10.1158/1535-7163.MCT-14-0755-T Abstract The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. Here, we show that mebendazole, a benzamidazole with a long history [...]

Authors: Lucas JM, Heinlein C, Kim T, Hernandez SA, Malik MS, True LD PMID: 25122198 PMCID: PMC4409786 DOI: 10.1158/2159-8290.CD-13-1010 Abstract TMPRSS2 is an androgen-regulated cell-surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastases. Through the generation of mouse [...]

Auhtors: Das A, Durrant D, Alloum FN, Xi L, Kukreja RC PMID: 25444755 PMCID: PMC4494657 DOI: 10.1016/j.pharmthera.2014.10.003 Abstract The phosphodiesterase 5 (PDE5) inhibitors, including sildenafil (Viagra™), vardenafil (Levitra™), and tadalafil (Cialis™) have been developed for treatment of erectile dysfunction. Moreover, sildenafil and tadalafil are used for the management of pulmonary arterial hypertension in patients. Since [...]

Auhtors: Garcia DO, Thomson CA PMID: 25335787 PMCID: PMC4470419 DOI: 10.1177/0884533614551969 Abstract There has been an increase in the cancer survivor population in the United States over the past several decades primarily due to improvements in early detection of first malignancies and effective treatment modalities. A wealth of evidence has demonstrated that regular physical activity [...]

Auhtors: Bourdel-Marchasson I, Blanc-Bisson C, Doussau A, Germain C, Blanc JF, Dauba J, et al. PMID: 25265392 PMCID: PMC4181649 DOI: 10.1371/journal.pone.0108687 Abstract Objective: We tested the effect of dietary advice dedicated to increase intake in older patients at risk for malnutrition during chemotherapy, versus usual care, on one-year mortality. Method: We conducted a multicentre, open-label [...]