Auhtors: Shukla SK, Gebregiworgis T, Purohit V, Chaika NV, Gunda V, Radhakrishnan P, et al. PMID: 25228990 PMCID: PMC4165433 DOI: 10.1186/2049-3002-2-18 Abstract Background: Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known as cancer cachexia. [...]

Auhtors: Petsiou EI, Mitrou PI, Raptis SA, Dimitriadis GD PMID: 25168916 DOI: 10.1111/nure.12125 Abstract The aim of this review is to summarize the effects of vinegar on glucose and lipid metabolism. Several studies have demonstrated that vinegar can help reduce hyperglycemia, hyperinsulinemia, hyperlipidemia, and obesity. Other studies, however, have shown no beneficial effect on metabolism. [...]

Auhtors: Beury DW, Parker KH, Nyandjo M, Sinha P, Carter KA, Ostrand-Rosenberg S PMID: 25170116 PMCID: PMC4226789 DOI: 10.1189/jlb.3A0414-210R Abstract MDSC and macrophages are present in most solid tumors and are important drivers of immune suppression and inflammation. It is established that cross-talk between MDSC and macrophages impacts anti-tumor immunity; however, interactions between tumor cells [...]

Authors: Brown R, Sam CH, Gxreen T, Wood S PMID: 25144853 DOI: 10.3109/19390211.2014.950783 Abstract Chewing gum alleviates symptoms of gastro-esophageal reflux (GER) following a refluxogenic meal. GutsyGum(tm), a chewing gum developed to alleviate the symptoms of GER contains calcium carbonate, with a proprietary blend of licorice extract, papain, and apple cider vinegar (GiGs®). The efficacy [...]

Auhtors: Urbinello D, Joseph W, Verloock L, Martens L, Röösli M PMID: 25127524 DOI: 10.1016/j.envres.2014.07.003 Abstract Background: The rapid development and increased use of wireless telecommunication technologies led to a substantial change of radio-frequency electromagnetic field (RF-EMF) exposure in the general population but little is known about temporal trends of RF-EMF in our everyday environment. [...]

Authors: Rossignol JF PMID: 25108173 PMCID: PMC7113776 DOI: 10.1016/j.antiviral.2014.07.014 Abstract Originally developed and commercialized as an antiprotozoal agent, nitazoxanide was later identified as a first-in-class broad-spectrum antiviral drug and has been repurposed for the treatment of influenza. A Phase 2b/3 clinical trial recently published in The Lancet Infectious Diseases found that oral administration of nitazoxanide [...]

Auhtors: Bannister CA, Holden SE, Jenkins-Jones S, Morgan CL, Halcox JP, Schernthaner G, et al. PMID: 25041462 DOI: 10.1111/dom.12354 Abstract Aims: Clinical and observational studies have shown an increased risk of cardiovascular events and death associated with sulphonylureas versus metformin. However, it has never been determined whether this was due to the beneficial effects of [...]

Authors: Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, Ortiz M, O'Sullivan CK PMID: 25050823 DOI: 10.1021/jf5014633 Abstract Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and metabolic pathways. Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act [...]

Auhtors: Labelle M, Begum S, Hynes RO PMID: 25024172 PMCID: PMC4121772 DOI: 10.1073/pnas.1411082111 Abstract During metastasis, host cells are recruited to disseminated tumor cells to form specialized microenvironments ("niches") that promote metastatic progression, but the mechanisms guiding the assembly of these niches are largely unknown. Tumor cells may autonomously recruit host cells or, alternatively, host [...]

Auhtors: Gandini S, Puntoni M, Heckman-Stoddard BM, Dunn BK, Ford L, DeCensi A, Szabo E PMID: 24985407 PMCID: PMC4154969 DOI: 10.1158/1940-6207.CAPR-13-0424 Abstract Previous meta-analyses have shown that the antidiabetic agent metformin is associated with reduced cancer incidence and mortality. However, this effect has not been consistently demonstrated in animal models and recent epidemiologic studies. We [...]