Auhtors: Labelle M, Begum S, Hynes RO PMID: 25024172 PMCID: PMC4121772 DOI: 10.1073/pnas.1411082111 Abstract During metastasis, host cells are recruited to disseminated tumor cells to form specialized microenvironments ("niches") that promote metastatic progression, but the mechanisms guiding the assembly of these niches are largely unknown. Tumor cells may autonomously recruit host cells or, alternatively, host [...]

Auhtors: McCarty OJ, Mousa SA, Bray PF, Konstantopoulos K PMID: 10961878 Abstract Accumulating evidence suggests that successful metastatic spread may depend on the ability of tumor cells to undergo extensive interactions with platelets. However, the mechanisms mediating tumor cell adhesion to platelets under conditions of flow remain largely unknown. Therefore, this study was designed to [...]

Auhtors: Heinmoller E, Weinel RJ, Heidtmann HH, Salge U, Seitz R, Schmitz I, et al. PMID: 8954171 DOI: 10.1007/BF01209121 Abstract We investigated the ability of human lung cancer cells of different histological subtypes to cause platelet aggregation. Tumor-cell-induced platelet aggregation (TCIPA) was studied in vitro in 13 human lung cancer cell lines [small-cell lung cancer [...]