Authors: LaRocca TJ, Gioscia-Ryan RA, Hearon CM, Seals DR PMID: 23612189 PMCID: PMC3700669 DOI: 10.1016/j.mad.2013.04.004 Abstract Arterial aging, characterized by stiffening of large elastic arteries and the development of arterial endothelial dysfunction, increases cardiovascular disease (CVD) risk. We tested the hypothesis that spermidine, a nutrient associated with the anti-aging process autophagy, [...]

Authors: Fletcher RH doi:10.1001/jamainternmed.2013.2305 Abstract Vitamin deficiency diseases, such as pellagra, rickets, beriberi, night blindness, and scurvy, used to account for an enormous burden of suffering worldwide. One by one, the underlying dietary deficiencies were defined, and, in the early part of the 20th century, the chemical structures of the missing nutrients were identified. While [...]

Authors: Minois N, Bauer MA, Rockenfeller P, Eisneber T, Brandhorst S, Kroemer G PMID: 23059820 PMCID: PMC3481127 doi: 10.1038/cddis.2012.139 Abstract The naturally occurring polyamine spermidine (Spd) has recently been shown to promote longevity across species in an autophagy-dependent manner. Here, we demonstrate that Spd improves both survival and locomotor activity of the fruit fly Drosophila [...]

Authors: Misra HS, rajpurohit YS, Khairnar NP. PMID: 22581337 DOI: 10.1007/s12038-012-9195-5 Abstract Pyrroloquinoline-quinine (PQQ) was initially characterized as a redox cofactor for membrane-bound dehydrogenases in the bacterial system. Subsequently, PQQ was shown to be an antioxidant protecting the living cells from oxidative damage in vivo and the biomolecules from artificially produced reaction oxygen species in [...]

Authors: Skurikhin EG, Andreeva TV, Khnelevskaya ES, Ermolaeva LA, Pershina OV, Krupin VA PMID: 22803125 DOI: 10.1007/s10517-012-1567-1 Abstract The effects of antiserotonin preparation on the development of the connective tissue in the lungs, reaction of the blood system, and the content of hemopoietic stem cells, committed hemopoietic and stromal precursors in BM, spleen, and peripheral [...]

Authors: Wu C, Li A, Leng Y, Kang J PMID: 22054065 DOI: 10.1089/dna.2011.1401 Abstract Recent studies suggest that change of macrophage phenotype (M1/M2) is associated with autoimmune diseases. Sodium valproate (VPA) is a class I histone deacetylase (HDAC) inhibitor, which has immunomodulatory function in graft-versus-host disease. However, its impact on macrophage polarization has not been [...]

Authors: Titos E, Rius B, Gonzalez-Periz A, Lopez-Vicario C, Arroyo V, Claria J PMID: 22013115 DOI: 10.4049/jimmunol.1100225 Abstract We recently demonstrated that ω-3-polyunsaturated fatty acids ameliorate obesity-induced adipose tissue inflammation and insulin resistance. In this study, we report novel mechanisms underlying ω-3-polyunsaturated fatty acid actions on adipose tissue, adipocytes, and stromal vascular cells (SVC). [...]

Authors: Clarke JD, Hsu A, Riedl K, Bella D, Stevens JF, Ho E PMID: 21816223 PMCID: PMC3183106 DOI: 10.1016/j.phrs.2011.07.005 Abstract Broccoli consumption may reduce the risk of various cancers and many broccoli supplements are now available. The bioavailability and excretion of the mercapturic acid pathway metabolites isothiocyanates after human consumption of broccoli supplements has not [...]

Authors: Morselli E, Marino G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S et al. PMID: 21339330 PMCID: PMC3044119 DOI: 10.1083/jcb.201008167 Abstract Autophagy protects organelles, cells, and organisms against several stress conditions. Induction of autophagy by resveratrol requires the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 (SIRT1). In this paper, we show that the acetylase inhibitor [...]

Authors: Walle T PMID: 21261636 DOI: 10.1111/j.1749-6632.2010.05842.x Abstract This paper reviews our current understanding of the absorption, bioavailability, and metabolism of resveratrol, with an emphasis on humans. The oral absorption of resveratrol in humans is about 75% and is thought to occur mainly by transepithelial diffusion. Extensive metabolism in the intestine and liver results in [...]