Authors: Morselli E, Galluzzi L, Kepp O, Criollo A, Maiuri MC, Madeo F PMID: 20157579 PMCID: PMC2815753 DOI: 10.18632/aging.100110 Abstract Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced [...]

Authors: Eisenberg T, Knauer H, Schauer A, Buttner S, Carmona-Gutierrez D, Ring J et al. PMID: 19801973 DOI: 10.1038/ncb1975 Abstract Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose [...]

Authors: McHugh GJ, Graber ML, Freebairn RC PMID: 18714631 DOI: 10.1177/0310057X0803600413 Abstract Although daily ingestion of high-dose vitamin C is generally regarded as largely innocuous, fatal nephrotoxicity can occur in some rare circumstances. We report a case where the patient, who chose to forgo any advanced conventional medical intervention (dialysis and mechanical ventilation), had failed [...]

Authors: Siso A, Ramos-Casals M, Bove A, Soria N, Testi A, Plaza J PMID: 18413408 DOI: 10.1177/0961203307086503 Abstract The aim of this study was to analyze the effect of exposure to antimalarial drugs at diagnosis of lupus nephritis on the outcome of the disease, especially renal failure, comorbid processes, and survival. We analyzed a cohort [...]

Authors: Ruiz-Irastorza G, Khamashta MA PMID: 18413405 DOI: 10.1177/0961203307086643 Abstract No abstract available Keywords: Hydroxychloroquine, lupus Source: https://journals.sagepub.com/doi/pdf/10.1177/0961203307086643 Archive: https://archive.is/caIhQ

Authors: Liu SL, Li YH, Shi GY, Chen YH, Huang CW, Hong JS PMID: 17084265 DOI: 10.1016/j.jacc.2006.07.036 Abstract Objectives: We investigated whether naloxone could reduce macrophage activation and influence atherosclerotic lesion formation in mice. Background: Macrophages play an important role in the inflammatory process in atherosclerosis. Naloxone could inhibit activation of microglia, the resident macrophage [...]

Evidence accumulated over the last 5-10 years indicates that glucocorticoids (GCs) inhibit the production of interleukin (IL)-12, interferon (IFN)-gamma, IFN-alpha, and tumor necrosis factor (TNF)-alpha by antigen-presenting cells (APCs) and T helper (Th)1 cells, but upregulate the production of IL-4, IL-10, and IL-13 by Th2 cells.

M Shodell 1, F P Siegal PMID: 11544466 DOI: 10.1067/mai.2001.117928 Abstract Glucocorticoids are strongly immunosuppressive and are associated with reactivation of some intracellular infections. The plasmacytoid dendritic cell is a rare blood mononuclear cell detected through its production of IFN-alpha in response to herpes simplex virus and by surface immunophenotyping. We here report that [...]

Authors: Mashour S, Turner JF, Merrell R PMID: 10936161 DOI: 10.1378/chest.118.2.561 Abstract With the increased use of nonprescription vitamin supplementation, physicians involved in critical care must be aware of the potential complications of these medications. We report the case of a 31-year-old African-American man presenting to the emergency department with acute renal failure. He had [...]

Authors: Auer BL PMID: 9767367 DOI: 10.1046/j.1365-2362.1998.00349.x Abstract Background: Long-term or high-dosage consumption of vitamin C may play a role in calcium oxalate kidney stone formation. The present study was undertaken to determine the biochemical and physicochemical risk factors in a male subject who developed haematuria and calcium oxalate crystalluria after ingestion of large doses [...]