Auhtors: Shishehbor F, Mansoori A, Shirani F PMID: 28292654 DOI: 10.1016/j.diabres.2017.01.021 Abstract Objective: Postprandial hyperglycemia plays a decisive role in the development of chronic metabolic disorders. The effect of vinegar intake with a meal on postprandial glucose has been studied in several trials with conflicting results. Research methods and procedures: The purpose of the current [...]

Authors: Sorokowaka A, Drechsler E, Karwowski M, Hummel T PMID: 28040824 DOI: 10.4193/Rhino16.195 Abstract The neural plasticity of the olfactory system offers possibilities of treatment in terms of stimulation of the sense of smell, and different studies have suggested effectiveness of smell training, i.e., daily exposition to certain odors. To obtain reliable and precise estimates [...]

Authors: Jiang P PMID: 27753792 DOI: 10.1097/SHK.0000000000000769 Abstract Hypomagnesemia is commonly seen but frequently overlooked in critically ill patients in intensive care unit (ICU). However, the strength and consistency of the effect of hypomagnesemia on outcomes in critically ill patients remain controversial. In this report, we performed a systematic review and [...]

Authors: Rosa DD, Dias MM, Grzeskowiak LM, Reis SA. PMID: 28222814 DOI: 10.1017/S0954422416000275 Abstract Kefir is fermented milk produced from grains that comprise a specific and complex mixture of bacteria and yeasts that live in a symbiotic association. The nutritional composition of kefir varies according to the milk composition, the microbiological composition of the grains [...]

Auhtors: Hamer J, Warner E PMID: 28246240 PMCID: PMC5318212 DOI: 10.1503/cmaj.160464 Abstract Although more than 90% of patients with breast cancer have early stage disease at diagnosis, about 25% will eventually die of distant metastasis.1 Many patients with breast cancer seek information from a variety of sources about behaviours that may reduce their risk of [...]

Auhtors: Kniotek M, Boguska A PMID: 28316997 PMCID: PMC5337856 DOI: 10.1155/2017/4541958 Abstract Sildenafil, a type 5 phosphodiesterase inhibitor (PDE5-I), is primarily used for treating erectile dysfunction. Sildenafil inhibits the degradation of cyclic guanosine monophosphate (cGMP) by competing with cGMP for binding site of PDE5. cGMP is a secondary messenger activating protein kinases and a common [...]

Authors: Kniotek M, Boguska A PMID: 28316997 PMCID: PMC5337856 DOI: 10.1155/2017/4541958 Abstract Sildenafil, a type 5 phosphodiesterase inhibitor (PDE5-I), is primarily used for treating erectile dysfunction. Sildenafil inhibits the degradation of cyclic guanosine monophosphate (cGMP) by competing with cGMP for binding site of PDE5. cGMP is a secondary messenger activating protein kinases and a common [...]

Auhtors: Puchalska P, Crawford PA PMID: 28178565 PMCID: PMC5313038 DOI: 10.1016/j.cmet.2016.12.022 Abstract Ketone body metabolism is a central node in physiological homeostasis. In this review, we discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and organism performance in varying nutrient states and protect from inflammation and injury in multiple organ systems. Traditionally [...]

Authors: Rich GT. PMID: 28165426 doi: 10.3390/nu9020111 PMCID: PMC5331542 Abstract We have studied the uptake of quercetin aglycone into CaCo-2/TC7 cells in the presence and absence of mixed micelles that are present in the human small intestine. The micelles inhibited the transport of quercetin into the cells. To gain an understanding of why this is [...]

Auhtors: Nowell CS, Radtke F PMID: 28154375 DOI: 10.1038/nrc.2016.145 Abstract The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation over recent decades has revealed how the role of Notch [...]