Authors: Christofferson T Abstract A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis. In the wake of the Cancer Genome Atlas project's failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. [...]

Auhtors: Xing Y, Liqi Z, Jian L, Qinghua Y, Qian Y PMID: 28203548 PMCID: PMC5285722 DOI: 10.3389/fcimb.2017.00021 Abstract Previous reports have demonstrated that the second-generation tetracycline derivative doxycycline (DOX) interrupts mitochondrial proteostasis and physiology, inhibits proliferation of many cell types, and induces apoptosis. However, the effects of DOX, which is widely used in porcine husbandry [...]

Authors: Nichols AJ, Hughs OB, Canazza A, Zaiac M PMID: 28367262 PMCID: PMC5367873 Abstract Objective: To evaluate the effectiveness of a novel oral supplement, Forti5®, containing green tea extract, omega 3 and 6 fatty acids, cholecalciferol, melatonin, beta-sitosterol, and soy isoflavones, and in the management of subjects with androgenetic alopecia. Design: A prospective case series [...]

Auhtors: Antoni R, Johnston KL, Collins AL, Robertson MD. PMID: 28091348 DOI: 10.1017/S0029665116002986 Abstract Two intermittent fasting variants, intermittent energy restriction (IER) and time-restricted feeding (TRF), have received considerable interest as strategies for weight-management and/or improving metabolic health. With these strategies, the pattern of energy restriction and/or timing of food intake are altered so that [...]

Auhtors: Ohayon M, Wickwire EM, Hirshkowitz M, Albert SM, Avidan A, Daly FJ, et al. PMID: 28346153 DOI: 10.1016/j.sleh.2016.11.006 Abstract Objectives: To provide evidence-based recommendations and guidance to the public regarding indicators of good sleep quality across the life-span. Methods: The National Sleep Foundation assembled a panel of experts from the sleep community and representatives [...]

Authors: Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J PMID: 27940189 DOI: 10.1016/j.chest.2016.11.036 Abstract Background: The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. Methods: In this retrospective before-after clinical study, we compared the outcome and clinical course of [...]

Auhtors: Zou K, Zhao L, Young A, Zhand H-Y, Li B, Zhu W-L, et al. PMID: 27917872 PMCID: PMC5309756 DOI: 10.1038/aps.2016.125 Abstract It has been widely recognized that inflammation, particularly chronic inflammation, can increase the risk of cancer and that the simultaneous treatment of inflammation and cancer may produce excellent therapeutic effects. Berberine, an alkaloid [...]

Auhtors: Sung MM, Kim TT, Denou E, Soltys CL, Hamza SM, Byrne NJ, et al. PMID: 27903747 DOI: 10.2337/db16-0680 Abstract Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes [...]

Authors: Larsson P, Alwis I, Niego B, Glise L, Daglas M, Jackson SP PMID: 27706906 DOI: 10.1111/jth.13527 Abstract Essentials Stimulating endogenous fibrinolysis could be a novel antithrombotic strategy. The effect of valproic acid on endothelial tissue plasminogen activator in mice was investigated. Valproic acid increased tissue plasminogen activator expression in vascular endothelium. Valproic acid reduced [...]

Auhtors: Mattson MP, Longo VD, Harvie M PMID: 27810402 PMCID: PMC5411330 DOI: 10.1016/j.arr.2016.10.005 Abstract Humans in modern societies typically consume food at least three times daily, while laboratory animals are fed ad libitum. Overconsumption of food with such eating patterns often leads to metabolic morbidities (insulin resistance, excessive accumulation of visceral fat, etc.), particularly when [...]