Authors:Hemila H. PMID: PMC5418896 DOI: 10.1177/2054270417694291 Abstract Objective: To compare the efficacy of zinc acetate lozenges with zinc gluconate lozenges in common cold treatment and to examine the dose-dependency of the effect. Design: Meta-analysis. Setting: Placebo-controlled zinc lozenge trials, in which the zinc dose was > 75 mg/day. The pooled effect of zinc lozenges on [...]

Auhtors: Zhao X, Qu J, Sun Y, Wang J, Liu x, Wang F, et al. PMID: 28427165 PMCID: PMC5444766 DOI: 10.18632/oncotarget.15736 Abstract Purpose: Tumor associated macrophages (TAMs) are important prognostic factors and have been proved to be associated with the invasion and migration of various cancer. However, the relationship between TAMs and breast cancer outcomes [...]

Auhtors: Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, et al. PMID: 28436999 PMCID: PMC5892208 DOI: 10.3322/caac.21397 Abstract Answer questions and earn CME/CNE Patients with breast cancer commonly use complementary and integrative therapies as supportive care during cancer treatment and to manage treatment-related side effects. However, evidence supporting the use of [...]

Authors: Menezes RR, Godin AM, Rodrigues FF, Coura GM, Melo IS, Brito AM PMID: 28958614 DOI: 10.1016/j.pharep.2017.04.011 Abstract Background: The effects induced by thiamine and riboflavin, isolated or in association with corticosteroids, in models of chronic inflammation are not known. Thus, we evaluated the effect induced by these B vitamins, isolated or in association with [...]

Auhtors: Reiter RJ, Rosales-Corral SA, TTan DX, Acuna-Castroviejo D, Qin L, Yang SF, Xu K PMID: 28420185 PMCID: PMC5412427 DOI: 10.3390/ijms18040843 Abstract There is highly credible evidence that melatonin mitigates cancer at the initiation, progression and metastasis phases. In many cases, the molecular mechanisms underpinning these inhibitory actions have been proposed. What is rather perplexing, [...]

Authors: Patel AB, Theoharides TC PMID: 28404689 DOI: 10.1124/jpet.117.240564 Abstract Mast cells (MCs) are critical for allergic reactions but are also important in inflammatory processes. Stimulation by neuropeptides, such as substance P (SP) and neurotensin (NT), leads to release of preformed molecules stored in numerous MC secretory granules and newly synthesized proinflammatory mediators, including tumor [...]

Auhtors: Medysky ME, Temesi J, Culos-Reed SN, Millet GY PMID: 28392007 DOI: 10.1016/j.neucli.2017.03.001 Abstract Cancer-related fatigue (CRF) is a commonly reported and debilitating side effect of cancer and/or cancer treatment. Sleep disorders are also highly reported in the cancer population; however it is unknown if sleep is associated with fatigue. In the general population, exercise [...]

Auhtors: Musella M, Manic G, De Maria R, Vitale I, Sistigu A PMID: 28638743 PMCID: PMC5467995 DOI: 10.1080/2162402X.2017.1314424 Abstract If there is a great new hope in the treatment of cancer, the immune system is it. Innate and adaptive immunity either promote or attenuate tumorigenesis and so can have opposing effects on the therapeutic outcome. [...]

Auhtors: Cao Y, Wu K, Mehta R, Drew DA, Song M, Lochhead P, et al. PMID: 28377387 PMCID: PMC5628103 DOI: 10.1136/gutjnl-2016-313413 Abstract Objective: Recent evidence suggests that antibiotic use, which alters the gut microbiome, is associated with an increased risk of colorectal cancer. However, the association between antibiotic use and risk of colorectal adenoma, the [...]

Auhtors: León D, Uribe E, Zambrano A, Salas M PMID: 28272357 PMCID: PMC6155386 DOI: 10.3390/molecules22030398 Abstract Resveratrol-a polyphenol of natural origin-has been the object of massive research in the past decade because of its potential use in cancer therapy. However, resveratrol has shown an extensive range of cellular targets and effects, which hinders the use [...]