Auhtors: De Santi M, Baldelli G, Diotallevi A, Galluzzi L, Schiavano GF, Brandi G PMID: 30635619 PMCID: PMC6329809 DOI: 10.1038/s41598-018-37247-6 Abstract Autophagy is a cellular mechanism by which cells degrade intracellular components in lysosomes, maintaining cellular homeostasis. It has been hypothesized that autophagy could have a role in cancer prevention through the elimination of damaged [...]

Auhtors: Miyata Y, Shida Y, Hakariya T, Sakai H PMID: 30621039 PMCID: PMC6337309 DOI: 10.3390/molecules24010193 Abstract Prostate cancer is the most common cancer among men. Green tea consumption is reported to play an important role in the prevention of carcinogenesis in many types of malignancies, including prostate cancer; however, epidemiological studies show conflicting results regarding [...]

Auhtors: Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, et al. PMID: 30415629 PMCID: PMC6425757 DOI: 10.1056/NEJMoa1809944 Abstract Background: It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. Methods: We conducted a nationwide, randomized, placebo-controlled trial, with [...]

Auhtors: Sung SJ, Kim H-K, Hong Y-K, Joe YA PMID: 30642153 PMCID: PMC6319545 DOI: 10.4062/biomolther.2018.222 Abstract Mebendazole (MBZ), a microtubule depolymerizing drug commonly used for the treatment of helminthic infections, has recently been noted as a repositioning candidate for angiogenesis inhibition and cancer therapy. However, the definite anti-angiogenic mechanism of MBZ remains unclear. In this [...]

Auhtors: Reddy P, Edwards LR PMID: 28471760 DOI: 10.1097/MJT.0000000000000538 Abstract Background: Vitamin D and magnesium (Mg) are some of the most studied topics in medicine with enormous implications for human health and disease. Majority of the adults are deficient in both vitamin D and magnesium but continue to go unrecognized by many health care professionals. [...]

Auhtors: Chandrasekaran B, Pal D, Kolluru V, Tyagi A, Baby B, Dahiya NR, et al. PMID: 30124785 PMCID: PMC6314334 DOI: 10.1093/carcin/bgy109 Abstract Chemopreventive effects and associated mechanisms of withaferin A (WA) against intestinal and colon carcinogenesis remain unknown. We investigated the chemopreventive effect of WA on transgenic adenomatous polyposis coli (APCMin/+) mouse and chemically induced [...]

Auhtors: Chinopoulos C, Seyfried TN PMID: 30909720 PMCID: PMC6311572 DOI: 10.1177/1759091418818261 Abstract Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit mitochondrial abnormalities incompatible with energy production through oxidative phosphorylation (OxPhos). Under such conditions, the mitochondrial F0-F1 ATP synthase operates [...]

Auhtors: Wang W, Liu Y, Guo J, He H, Mi X, Chen C, et al. PMID: 30563983 PMCID: PMC6299090 DOI: 10.1038/s41389-018-0106-y Abstract Tumor-associated macrophages (TAMs), the main part of immune cells in tumor microenvironment (TME), play a potent role in promoting tumorigenesis through mechanisms such as stimulating angiogenesis, enhancing tumor migration and suppressing antitumor immunity. [...]

Authors: Beckman JA PMID: 30560579 PMCID: PMC6516871 doi: 10.1002/14651858.CD004437.pub5 AbstractBackgroundThrombolytic therapy is usually reserved for patients with clinically serious or massive pulmonary embolism (PE). Evidence suggests that thrombolytic agents may dissolve blood clots more rapidly than heparin and may reduce the death rate associated with PE. However, there are still concerns about the possible risk [...]

Auhtors: Su J, Li D, Chen Q, Li M, Su L, Luo T, et al. PMID: 30619178 PMCID: PMC6304348 DOI: 10.3389/fmicb.2018.03099 Abstract Increasing evidence highlights the cardinal role of gut microbiota in tumorigenesis and chemotherapy outcomes. Paclitaxel (PTX), although as a first-line chemotherapy reagent for breast cancer, still requires for improvement on its efficacy and [...]