Auhtors: D'Errico G, Alonso-Nocelo M, Vallespinos M, Hermann PC, Alcalá S, García CP, et al. PMID: 30936462 DOI: 10.1038/s41388-019-0803-9 Abstract Pancreatic ductal adenocarcinoma (PDAC) is an inherently chemoresistant tumor. Chemotherapy leads to apoptosis of cancer cells, and in previous studies we have shown that tumor-associated macrophage (TAM) infiltration increases following chemotherapy in PDAC. Since one [...]

Auhtors: Yan L, Sundaram S, Mehus AA, Picklo MJ PMID: 30952713 DOI: 10.21873/anticanres.13280 Abstract Background/aim: Obesity is a risk factor for cancer. Disruption of the daily feeding and fasting rhythm can contribute to obesity. This study tested the hypothesis that time-restricted feeding (TRF) attenuates obesity-enhanced metastasis. Materials and methods: In a spontaneous metastasis model of [...]

Authors: Stoehr JR, Choi JN, Colavincenzo M, Vanderweil S PMID: 30604379 DOI: 10.1007/s40257-018-0409-y Abstract Topical minoxidil is a well-known and often-utilized drug in dermatological practice for the treatment of alopecia. It was approved by the United States Food and Drug Administration for the treatment of androgenetic alopecia in 1988. Since its approval, minoxidil has been [...]

Auhtors: Cassetta L, Fragkogianni S, Sims AH, Swierczak A, Forrester LM, Zhang H, et al. PMID: 30930117 PMCID: PMC6472943 DOI: 10.1016/j.ccell.2019.02.009 Abstract The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human cancer are poorly understood. Here, we show that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and [...]

Auhtors: Tseng CH PMID: 30896668 PMCID: PMC6709307 DOI: 10.1097/MD.0000000000014955 Abstract Background: The relationship between metformin use and the risk of prostate cancer is still inconclusive. Therefore, we performed a systematic review and meta-analysis of all eligible cohort studies to evaluate a potential association of metformin use with prostate cancer risk. Methods: A comprehensive literature search [...]

Authors: Reddy P, Edwards LR. PMID: 28471760 DOI: 10.1097/MJT.0000000000000538 Abstract Background: Vitamin D and magnesium (Mg) are some of the most studied topics in medicine with enormous implications for human health and disease. Majority of the adults are deficient in both vitamin D and magnesium but continue to go unrecognized by [...]

Authors: Finisguerra A, Borgatti R, Urgesi C PMID: 30787895 PMCID: PMC6373438 DOI: 10.3389/fpsyg.2019.00135 Abstract In the last years, there has been a growing interest in the application of different non-invasive brain stimulation techniques to induce neuroplasticity and to modulate cognition and behavior in adults. Very recently, different attempts have been made to induce functional plastic [...]

Auhtors: Sissung TM, Schmidt KT, Figg WD DOI:https://doi.org/10.1016/S1470-2045(19)30003-8 Abstract Insulin is responsible for cellular glucose uptake and mitogenic signalling cascades in cancer cells,1 and can promote cell proliferation, survival, invasiveness, angiogenesis, immunomodulation, and chemoresistance.1–3 Why, then, would some medical practitioners claim that the use of insulin and glucose can improve the outcomes of patients with [...]

Authors: Ma W, Zhang J, Guo L, Wang Y, Lu S, Wang Z et al. PMID: 30956636 PMCID: PMC6449667 Abstract Macrophages are important mediators of inflammatory cardiovascular diseases, and various macrophage phenotypes exert opposite effects during inflammation. In our previous study, we proved that suppressed androgen receptor (AR) alleviated inflammation during experimental autoimmune myocarditis (EAM). [...]

Auhtors: Li C, Wang Q, Shen S, Wei X, Li G PMID: 30653763 PMCID: PMC6590488 DOI: 10.1002/ptr.6273 Abstract Tumor metastasis is still the leading cause of melanoma mortality. Luteolin, a natural flavonoid, is found in fruits, vegetables, and medicinal herbs. The pharmacological action and mechanism of luteolin on the metastasis of melanoma remain elusive. In [...]