Auhtors: Lopresti AL, Smith SJ, Malvi H, Kodgule R PMID: 31517876 PMCID: PMC6750292 DOI: 10.1097/MD.0000000000017186 Abstract Background: Ashwagandha (Withania somnifera (L.) Dunal) is a herb traditionally used to reduce stress and enhance wellbeing. The aim of this study was to investigate its anxiolytic effects on adults with self-reported high stress and to examine potential mechanisms [...]

Authors: Kunnumakkara AB, Harsha C, Banik K, Vikkurthi R, Sailo BL, Bordoloi D PMID: 31361978 DOI: 10.1080/17425255.2019.1650914 Abstract Introduction: Since ancient times, turmeric has been used in several folklore remedies against various ailments. The principal component of turmeric is curcumin and its efficacy has been advocated in various in vitro, in vivo and clinical studies [...]

Authors: Kunnumakkara AB, Harsha C, Banik K, Vikkurthi R, Sailo BL, Bordoloi D PMID: 31361978 DOI: 10.1080/17425255.2019.1650914 Abstract Introduction: Since ancient times, turmeric has been used in several folklore remedies against various ailments. The principal component of turmeric is curcumin and its efficacy has been advocated in various in vitro, in vivo and clinical studies [...]

Auhtors: Cornet-Masana JM, Banús-Mulet A, Carbó JM, Torrente MÁ, Guijarro F, Cuesta-Casanovas L, et al. PMID: 31473184 PMCID: PMC6796581 DOI: 10.1016/j.ebiom.2019.08.021 Abstract Background: Despite great efforts to identify druggable molecular targets for AML, there remains an unmet need for more effective therapies. Methods: An in silico screening was performed using Connectivity Maps to identify FDA-approved [...]

Auhtors: Amaravadi RK, Kimmelman AC, Debnath J PMID: 31434711 PMCID: PMC7306856 DOI: 10.1158/2159-8290.CD-19-0292 Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit [...]

Authors: Amaravadi RK, Kimmelman AC, Debnath J PMID: 31434711 PMCID: PMC7306856 DOI: 10.1158/2159-8290.CD-19-0292 Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit [...]

Authors: Matsushita H, Latt HM, Koga Y, Nishiki T, Matsui H PMID: 31400490 DOI: 10.1016/j.neuroscience.2019.07.046 Abstract Clinical reports show that oxytocin (OT) is related to stress-related disorders such as depression, anxiety disorder, and post-traumatic stress disorder. Two key structures in the brain should be paid special attention with regard to stress regulation, namely, the hypothalamus [...]

Auhtors: Yin Z, Ma T, Huang B, Lin L, Zhou Y, Yan J, et al. PMID: 31307515 PMCID: PMC6631643 DOI: 10.1186/s13046-019-1313-x Abstract Background: Exosomes from cancer cells or immune cells, carrying bio-macromolecules or microRNAs (miRNAs), participate in tumor pathogenesis and progression by modulating microenvironment. Our study aims to investigate the role of these microRNA-501-3p (miR-501-3p) [...]

Auhtors: Chazelas E, Srour B, Desmetz E, Kesse-Guyot E, Julia C, Deschamps V, et al. PMID: 31292122 PMCID: PMC6614796 DOI: 10.1136/bmj.l2408 Abstract Objective: To assess the associations between the consumption of sugary drinks (such as sugar sweetened beverages and 100% fruit juices), artificially sweetened beverages, and the risk of cancer. Design: Population based prospective cohort [...]

Authors: Morishita H, Mizushima N PMID: 31283377 DOI: 10.1146/annurev-cellbio-100818-125300 Abstract Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular [...]