Auhtors: Morishita H, Mizushima N PMID: 31283377 DOI: 10.1146/annurev-cellbio-100818-125300 Abstract Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular [...]

Auhtors: Agrawal S, Vamadevan P, Mazibuko N, Bannister R, Swery R, Wilson S PMID: 31316378 PMCID: PMC6610246 DOI: 10.3389/fphar.2019.00681 Abstract In oncology, preclinical and early clinical data increasingly support the use of a number of candidate "non-cancer" drugs in an off-label setting against multiple tumor types. In particular, metabolically targeted drugs show promise as adjuvant [...]

Auhtors: An KY, Morielli AR, Kang DW, Friedenreich CM, McKenzie DC, Gelmon K, et al. PMID: 31173341 DOI: 10.1002/ijc.32493 Abstract The Combined Aerobic and Resistance Exercise (CARE) Trial compared different types and doses of exercise performed during breast cancer chemotherapy. Here, we report the longer-term follow-up of patient-reported outcomes, health-related fitness and exercise behavior at [...]

Authors: Mohamed M, Lila AS, Shimizu T, Alaaeldin E, Hussein A, Sarhan HA et al. PMID: 31275462 PMCID: PMC6598536 DOI: 10.1080/14686996.2019.1627174 Abstract A commonly held view is that nanocarriers conjugated to polyethylene glycol (PEG) are non-immunogenic. However, many studies have reported that unexpected immune responses have occurred against PEG-conjugated nanocarriers. One unanticipated response is the [...]

Auhtors: Nayeem M, Chauhan K Abstract The aim of the review is to evaluate the oxidative potentials of Wheat, Sorghum grass, and Barley grass juices and its Anti diabetic activity. Diabetes mellitus is a major disease over worldwide many deaths every year. Now we have chosen the essential grasses juices which plays an important role [...]

Authors:Winska K, Maczka W, Lyczko J, Szumny A. PMID:PMC6612361 doi: 10.3390/molecules24112130 Abstract Herbs and the essential oils derived from them have been used from the beginning of human history for different purposes. Their beneficial properties have been applied to mask unpleasant odors, attract the attention of other people, add flavor and aroma properties to prepared [...]

Authors:Schnitzler P. PMID:31234166 DOI: 10.1159/000501062 Abstract Infections with herpes simplex virus type (HSV)-1 and HSV-2 are distributed worldwide. Although standard therapies with acyclovir and other synthetic drugs are available, the safety and efficacy of these drugs are limited due to the development of drug resistance and adverse side effects. The literature on essential oils and [...]

Authors: Hengartner MP, Ploderi M PMID: 31234169 DOI: 10.1159/000501215 Abstract Studies disagree whether antidepressants may trigger suicide attempts in adults with major depression. Some meta-analyses of randomized controlled trials (RCT) found significantly elevated rates of (attempted) suicide in antidepressant arms relative to placebo, whereas others did not. A recent study by Khan et al. likewise [...]

Auhtors: Ohue Y, Nishikawa H PMID: 31102428 PMCID: PMC6609813 DOI: 10.1111/cas.14069 Abstract Regulatory T (Treg) cells suppress abnormal/excessive immune responses to self- and nonself-antigens to maintain immune homeostasis. In tumor immunity, Treg cells are involved in tumor development and progression by inhibiting antitumor immunity. There are several Treg cell immune suppressive mechanisms: inhibition of costimulatory [...]

Auhtors: Sundaram S, Yan L PMID: 31188781 PMCID: PMC6594823 DOI: 10.18632/aging.102021 Abstract Aging increases the risk of cancer partly through alterations in the tissue microenvironment. Time-restricted feeding (TRF) is being proposed as an effective strategy to delay biological aging. In the present studies, we assessed the effect of long-term exposure to TRF on the emergence [...]