Authors: Tezgin D, Giardina C, Perdrizet GA, Hightower LE PMID: 32253741 PMCID: PMC7332662 doi: 10.1007/s12192-020-01100-5 Abstract We present new data on the effects of HBOT on human kidney (HK-2) cell metabolism using a SeaHorse XF Analyzer to evaluate separately the state of mitochondrial and glycolytic energy metabolism. The data are discussed in the context of [...]

Authors: Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. PMID: 32251768 PMCID: PMC7129059 DOI: 10.1016/j.antiviral.2020.104787 Abstract Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown to have broad-spectrum [...]

Authors: Kandeel M, Al-Nazawi M. PMID: 32251634 PMCID: PMC7194560 DOI: 10.1016/j.lfs.2020.117627 Abstract Aims: In December 2019, the Coronavirus disease-2019 (COVID-19) virus has emerged in Wuhan, China. In this research, the first resolved COVID-19 crystal structure (main protease) was targeted in a virtual screening study by of FDA approved drugs dataset. In addition, a knowledge gap [...]

Authors: McGonagle D, Sharif K, O'Regan A, Bridgewood C PMID: 32251717 PMCID: PMC7195002 DOI: 10.1016/j.autrev.2020.102537 Abstract Severe COVID-19 associated pneumonia patients may exhibit features of systemic hyper-inflammation designated under the umbrella term of macrophage activation syndrome (MAS) or cytokine storm, also known as secondary haemophagocytic lymphohistocytosis (sHLH). This is distinct from HLH associated with immunodeficiency [...]

Authors:Grant WB, Lahore H, McDonnell SL, Baggerly CA, French Cb, Aliaono JL. PMID:PMC7231123 DOI: 10.3390/nu12040988 Abstract The world is in the grip of the COVID-19 pandemic. Public health measures that can reduce the risk of infection and death in addition to quarantines are desperately needed. This article reviews the roles of vitamin D in reducing [...]

Authors: Salim B, Noureddine M. PMID: DOI:10.26434/chemrxiv.12055716.v1 Abstract The spread of the global COVID-19 pandemic, the lack of specific treatment and the urgent situation requires use of all resources to remedy this scourge. In the present study, using molecular docking, we identify new probable inhibitors of COVID-19 by molecules from Nigella sativa L, which is [...]

Authors: Keith P, Day M, Perkins L, Moyer L, Hewitt K, Wells A PMID: 32241301 PMCID: PMC7117947 DOI: 10.1186/s13054-020-2836-4 Abstract The novel coronavirus (“SARS-CoV-2”) outbreak has created a sense of panic globally and has the medical community rapidly searching for answers. An estimated 100,000 individuals have already been infected with nearly 3300 deaths attributed to [...]

The world is in the grip of the COVID-19 pandemic. Public health measures that can reduce the risk of infection and death in addition to quarantines are desperately needed. This article reviews the roles of vitamin D in reducing the risk of respiratory tract infections, knowledge about the epidemiology of influenza and COVID-19, and how vitamin D supplementation might be a useful measure to reduce risk.

Authors: Henry MB, Lippi G PMID: 32279018 PMCID: PMC7118619 DOI: 10.1016/j.jcrc.2020.03.011 Abstract The novel coronavirus disease 2019 (COVID-19) can induce acute respiratory distress syndrome (ARDS), which can progress to refractory pulmonary failure. In such cases, extracorporeal membrane oxygenation (ECMO) may be considered as a rescue therapy. In a study of ECMO for ARDS in patients [...]

Auhtors: Han MA, Storman D, Al-Rammahy H, Tang S, Hao Q, Leung G, et al. PMID: 32226046 PMCID: PMC7105118 DOI: 10.1371/journal.pone.0230721 Abstract Background: A number of studies have reported on associations between reproductive factors, such as delivery methods, number of birth and breastfeeding, and incidence of cancer in children, but systematic reviews addressing this issue [...]