Authors: Diep PT, Buemann B, Uvnas-Moberg K PMID: 34908992 PMCID: PMC8629037 DOI: 10.36131/CNEPUB20201703 Abstract After comparing the morbidity patterns of COVID-19 infections, variations of oxytocin levels and some properties of the neurohormone oxytocin, the authors put forward their hypothesis that oxytocin might constitute a safe, inexpensive and readily available treatment for this disease. Keywords: COVID-19, [...]

Authors: Ding X, Xu J, Zhou J, Long Q PMID: 32325282 PMCID: PMC7165099 DOI: 10.1016/j.ejrad.2020.109009 Abstract Purpose: To evaluate lung abnormalities on thin-section computed tomographic (CT) scans in patients with COVID-19 and correlate findings to duration of symptoms. Methods: In total, 348 CT scans in 112 patients were classified according to the time after the [...]

Authors: Moore JB, June CH PMID: 32303591 DOI: 10.1126/science.abb8925 Abstract In December 2019, a new strain of coronavirus, severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), was recognized to have emerged in Wuhan, China. Along with SARS-CoV and Middle East respiratory syndrome–coronavirus (MERS-CoV), SARS-CoV-2 is the third coronavirus to cause severe respiratory illness in humans, called coronavirus [...]

Authors: Gattinoni L, Chiumello D, Rossi S PMID: 32299472 PMCID: PMC7160817 DOI: 10.1186/s13054-020-02880-z Abstract Even though it can meet the ARDS Berlin definition, the COVID-19 pneumonia is a specific disease with peculiar phenotypes. Its main characteristic is the dissociation between the severity of the hypoxemia and the maintenance of relatively good respiratory mechanics. Indeed, the [...]

Authors: Gassen NC, Papies J, Bajaj T, Emanuel J, Wechmann K, Heinz DE et al. doi: https://doi.org/10.1101/2020.04.15.997254 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an acute threat to public health and the world economy, especially because no approved specific drugs or vaccines are available. Pharmacological modulation of metabolism-dependent cellular pathways such as autophagy [...]

Authors: Gattinoni L, Chiumello D, Caironi P, Busana M, Romitti F, Brazzi L PMID: 32291463 PMCID: PMC7154064 DOI: 10.1007/s00134-020-06033-2 Abstract The Surviving Sepsis Campaign panel recently recommended that “mechanically ventilated patients with COVID-19 should be managed similarly to other patients with acute respiratory failure in the ICU.” Yet, COVID-19 pneumonia, despite falling in most of [...]

Authors: Skalny AV, Rink L, Ajsuvakova OP, Aschner M, Gritsenko VA PMID: 32319538 PMCID: PMC7255455 DOI: 10.3892/ijmm.2020.4575 Abstract In view of the emerging COVID‑19 pandemic caused by SARS‑CoV‑2 virus, the search for potential protective and therapeutic antiviral strategies is of particular and urgent interest. Zinc is known to modulate antiviral and antibacterial immunity and regulate [...]

Authors: Hashem HE. DOI: 10.14744/ejmo.2020.36102 Abstract Objectives: The emergence and spread of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), led researchers around the world to study the crystal structure of the main protease (Mpro), 3-chymotrypsin-like cysteine protease, which is an essential enzyme for processing polyproteins. Inhibition of this [...]

Authors: Ye Q, Wang B, Mao J PMID: 32283152 PMCID: PMC7194613 DOI: 10.1016/j.jinf.2020.03.037 Abstract Cytokine storm is an excessive immune response to external stimuli. The pathogenesis of the cytokine storm is complex. The disease progresses rapidly, and the mortality is high. Certain evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, the severe deterioration [...]

Authors: Xu TT, Li H, Dai Z, Lau GK, Li BY, Zhu WL et al. PMID: 32268299 PMCID: PMC7185103 DOI: 10.18632/aging.103035 Abstract The natural polyamine spermidine and spermine have been reported to ameliorate aging and aging-induced dementia. However, the mechanism is still confused. An aging model, the senescence accelerated mouse-8 (SAMP8), was used in this [...]