Authors: Theoharides TC PMID: 32339387 PMCID: PMC7267424 DOI: 10.1002/biof.1633 Abstract The new coronavirus (severe acute pulmonary syndrome [SARS]‐CoV‐2) originated in China, where it spread rapidly, and has reached pandemic proportions because of its high rate of infectivity as well as high morbidity and mortality, associated with COVID‐19. This coronavirus infects by first binding to the [...]

Authors: Abdelnour L, Abdalla ME, Babiker S PMID: 32354690 PMCID: PMC7183987 DOI: 10.1016/j.jfma.2020.04.024 Abstract On Mar 23, 2020, a 69-year-old man presented to the Ulster Hospital in Northern Ireland after waking up with bilateral lower limb weakness three days prior to admission. He had numbness on both legs that lasted for hours and resolved. He [...]

Authors: Tan C, Huang Y, Shi F, Tan K, Ma Q, Chen Y PMID: 32281668 PMCID: PMC7262341 DOI: 10.1002/jmv.25871 Abstract COVID-19 has developed into a worldwide pandemic; early identification of severe illness is critical for controlling it and improving the prognosis of patients with limited medical resources. The present study aimed to analyze the characteristics [...]

Authors: Copin MC, Parmentier E, Duburcq T, Poissy J, Mathieu D PMID: 32328726 PMCID: PMC7178098 DOI: 10.1007/s00134-020-06057-8 Abstract In their editorial about ‘COVID-19 pneumonia: different respiratory treatment for different phenotypes’ Gattinoni et al. hypothesize a sequence of events in critically ill patients infected by SARS-CoV-2. They describe a type L characterized by a low elastance, [...]

Authors: Goren A, Vamo-Galvan S, Wambier CG, McCoy J PMID: 32301221 DOI: 10.1111/jocd.13443 Abstract A preliminary observation of high frequency of male pattern hair loss among admitted COVID-19 patients and suggest that androgen expression might be a clue to COVID-19 severity. Keywords: 5-alpha reductase; ACE2; SARS-CoV-2; TMPRSS2; androgenetic alopecia. Source: https://pubmed.ncbi.nlm.nih.gov/32301221/ Archive: https://archive.ph/BBGXS [...]

Authors: Varga Z, Flammer AJ, Steiger P, Habrecker M, Andermatt R, Zinkernagel AS PMID: 32325026 PMCID: PMC7172722 DOI: 10.1016/S0140-6736(20)30937-5 Abstract Cardiovascular complications are rapidly emerging as a key threat in coronavirus disease 2019 (COVID-19) in addition to respiratory disease. The mechanisms underlying the disproportionate effect of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection on patients [...]

Authors: Boretti A, Banik BK PMID: 32322486 PMCID: PMC7172861 DOI: 10.1016/j.phanu.2020.100190 Abstract The recent outbreak of Covid19 has required urgent treatments for numerous patients. No suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of WHO therapies of choice, that are two antivirals developed for other pathologies, is controversial. Therefore, alternative approaches [...]

Authors: Giamarellos-Bouboulis EJ, Netea MG, Rovina N, Akinosoglou K, Antoniadou A, Antonakos N et al. PMID: 32320677 PMCID: PMC7172841 DOI: 10.1016/j.chom.2020.04.009 Abstract Proper management of COVID-19 mandates better understanding of disease pathogenesis. The sudden clinical deterioration 7-8 days after initial symptom onset suggests that severe respiratory failure (SRF) in COVID-19 is driven by a unique [...]

Authors: Padmanabhan S, Padmanabhan K DOI:10.13140/RG.2.2.22854.83527 Abstract COVID-19 has tested the limits of our healthcare system with very few clear therapeutic options proven to date. Previous studies of SARS and MERS and now SARS-CoV-2 have clearly shown the significance of interferon response in altering disease severity/outcome. The broad anti-viral activity of Nitazoxanide stems from its [...]

Nair MP, Kandaswami C, Mahajan S, Chadha KC, Chawda R, Nair H. PMID: 12431781 DOI: 10.1016/s0167-4889(02)00328-2 Abstract Flavonoids are plant metabolites that are dietary antioxidants and exert significant anti-tumor, anti-allergic, anti-inflammatory and anti-viral effects. It is generally accepted that Th-1 derived cytokines such as IL-2, IFNgamma and IL-12 promote cellular immunity while Th-2 derived [...]