Authors: Patel AN, Desai SS, Grainger DW, Mehra MR Abstract Importance: There is no established anti-viral therapy for treating COVID-19 illness. Objective: To study the usefulness of Ivermectin, an antimicrobial therapy, in COVID-19 outcomes. Design: An international, multicenter, observational propensity-score matched case-controlled study using prospectively collected data on patients diagnosed with [...]

Authors: Rothlin RP, Vetulli HM, Duarte M, Pelorosso FG PMID: 32356926 PMCID: PMC7267340 DOI: 10.1002/ddr.21679 Abstract In late 2019, a new coronavirus emerged in Wuhan Province, China, causing lung complications similar to those produced by the SARS coronavirus in the 2002-2003 epidemic. This new disease was named COVID-19 and the causative virus SARS-CoV-2. The SARS-CoV-2 [...]

Authors:Marik PE, Kory P, Varon J. PMID:PMC7189189 doi: 10.1016/j.medidd.2020.100041 Abstract The COVID-19 pandemic has claimed over 150,000 lives worldwide. Infection with SARS-CoV-2 results in a broad spectrum of disease, with in excess of 80% of patients having few or no symptoms. What is striking about COVID-19 is the enormous variation in [...]

Authors: Villar J, Confalonieri M, Pastores SM, Meduri GU PMID: 32426753 PMCID: PMC7188431 DOI: 10.1097/CCE.0000000000000111 Abstract In December 2019, pneumonia associated with the novel coronavirus disease 2019 (COVID-19) emerged in Wuhan, China. On March 14, 2020, the World Health Organization (WHO) declared the coronavirus outbreak a pandemic with confirmed cases in 127 countries. This unprecedented [...]

The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly and people with diseases of chronic inflammation. Therefore, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks.

Authors: Leisman DE, Deutschman CS, Legrand M PMID: 32347323 PMCID: PMC7186535 DOI: 10.1007/s00134-020-06059-6 Abstract Current management guidelines for COVID-19 reflect the assumption that critically ill patients infected with SARS-CoV-2 develop acute respiratory distress syndrome (ARDS). However, emerging data and clinical reports increasingly suggest an alternative view that severe COVID-19 reflects a confluence of vascular dysfunction, [...]

Authors:Rhodes JM, Subramanian S, Laird E, Kenny RA. PMID:PMC7264531 DOI: 10.1111/apt.15777 Abstract Keywords: Source: https://pubmed.ncbi.nlm.nih.gov/32311755/ Archive: https://archive.is/hP7pW

Authors:Lau FH, Majumder R, Torabi R, Saeg F, Hoffman R, Cirillo JD. doi: https://doi.org/10.1101/2020.04.24.20075838 Abstract Background COVID-19 is a major pandemic that has killed more than 196,000 people. The COVID-19 disease course is strikingly divergent. Approximately 80-85% of patients experience mild or no symptoms, while the remainder develop severe disease. The mechanisms underlying these divergent [...]

Authors: Li MY, Li L, Zhang Y, Wang XS PMID: 32345362 PMCID: PMC7186534 DOI: 10.1186/s40249-020-00662-x Abstract Background: Since its discovery in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 2 180 000 people worldwide and has caused more than 150 000 deaths as of April 16, 2020. SARS-CoV-2, which is [...]

Authors: Tay MZ, Poh CM, Renia L, MacAry PA PMID: 32346093 PMCID: PMC7187672 DOI: 10.1038/s41577-020-0311-8 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic. Alongside investigations into the virology of SARS-CoV-2, understanding the fundamental physiological and immunological processes underlying the clinical manifestations of COVID-19 [...]