Authors: Cruz AF, Ruiz-Antoran B, Gomez AM, Lopez AS doi: https://doi.org/10.1101/2020.05.22.20110544 Abstract Objective We aim to determine the impact of steroid use in COVID-19 pneumonia in-hospital mortality. Design We performed a single-centre retrospective cohort study. Setting A University hospital in Madrid, Spain, during March 2020. Participants Patients admitted with SARS-CoV-2 pneumonia. Exposures Patients treated with [...]

Authors: Xu Q, Wang T, Quin X, Zha L PMID: 32448330 PMCID: PMC7246000 DOI: 10.1186/s13054-020-02991-7 Abstract Coronavirus disease 2019 (COVID-19) has rapidly spread around the world in the past 3 months and has now become a global public health crisis. The mortality of COVID-19 in some European cities exceeds 11%, and the fatality rate is [...]

Authors: Merchant HA DOI: 10.14293/S2199-1006.1.SOR-.PPURWMT.v1 Abstract While we wait for a confirmed drug or a vaccine for CoViD-19, it may be possible to intervene early to prevent the virus causing a severe disease to offer an alternative therapeutic strategy to control the pandemic. The global burden of CoViD-19 on healthcare system can be significantly reduced [...]

Authors: Tripathy S, Dassarma B, Roy S, Chabalala H, Matsabisa MG PMID: 32450198 PMCID: PMC7243790 DOI: 10.1016/j.ijantimicag.2020.106028 Abstract Chloroquine (CQ) and its analogue hydroxychloroquine (HCQ) have long been used worldwide as frontline drugs for the treatment and prophylaxis of human malaria. Since the first reported cases in Wuhan, China, in late December 2019, humans have [...]

Authors: Bryce C, Grimes Z, Pujadas E, Ahuja S, Beasley MB, Albrecht R et al. PMID: 33795830 PMCID: PMC8015313 DOI: 10.1038/s41379-021-00793-y Abstract BACKGROUND Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe, disproportionately affecting New York City. A comprehensive, integrative autopsy series that [...]

Authors: Freedberg DE, Conigliaro J, Sobieszczyk ME, Markowitz DD PMID: 32446698 PMCID: PMC7242191 doi: 10.1053/j.gastro.2020.05.053 Abstract Coronavirus Disease 2019 (COVID-19) caused 2 million cases and more than 150,000 deaths worldwide as of mid-April 2020.1 Clinical trials are under way to assess the efficacy of a variety of antiviral drugs; however, many of these drugs have [...]

Authors: Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T PMID: 32437596 PMCID: PMC7412750 DOI: 10.1056/NEJMoa2015432 Abstract Background: Progressive respiratory failure is the primary cause of death in the coronavirus disease 2019 (Covid-19) pandemic. Despite widespread interest in the pathophysiology of the disease, relatively little is known about the associated [...]

Authors: Teuwen LA, Geldhof V, Pasut A, Carmeliet P PMID: 32439870 PMCID: PMC7240244 DOI: 10.1038/s41577-020-0343-0 Abstract On the basis of emerging evidence from patients with COVID-19, we postulate that endothelial cells are essential contributors to the initiation and propagation of severe COVID-19. Here, we discuss current insights into the link between endothelial cells, viral infection [...]

Authors: Fatima S, Zaidi SS, Alsharidah AS, Alijaser FS, Banu N. PMID:PMC7295866 DOI: 10.1136/bmjnph-2020-000085 Abstract The immune system protects the host from pathogenic organisms (bacteria, viruses, fungi, parasites). To deal with this array of threats, the immune system has evolved to include a myriad of specialised cell types, communicating molecules and functional responses. The immune [...]

Authors: Willis MS, Monaghan SA, Miller ML, McKenna RW. PMID:PMC7295866 DOI: 10.1136/bmjnph-2020-000085 Abstract The immune system protects the host from pathogenic organisms (bacteria, viruses, fungi, parasites). To deal with this array of threats, the immune system has evolved to include a myriad of specialised cell types, communicating molecules and functional responses. The immune system is [...]