Authors:Calder PC. PMID:PMC7295866 DOI: 10.1136/bmjnph-2020-000085 Abstract The immune system protects the host from pathogenic organisms (bacteria, viruses, fungi, parasites). To deal with this array of threats, the immune system has evolved to include a myriad of specialised cell types, communicating molecules and functional responses. The immune system is always active, carrying out surveillance, but its [...]

Authors:Daneshkhah A, Eshein A, Subramanian H. doi: https://doi.org/10.1101/2020.04.08.20058578 Abstract Objectives To investigate the possible role of Vitamin D (Vit D) deficiency via unregulated inflammation in COVID-19 complications and associated mortality. Design The time-adjusted case mortality ratio (T-CMR) was estimated as the number of deceased patients on day N divided by the number of confirmed cases [...]

Authors: De Maio A, Hightower LE PMID: 32424591 PMCID: PMC7232923 DOI: 10.1007/s12192-020-01121-0 Abstract The current coronavirus disease 2019 (COVID-19) pandemic has become an unprecedented challenge for the healthcare system worldwide, with an overwhelming number of patients requiring clinical attention and an unacceptably high mortality rate within critical care facilities. COVID-19 is caused by a novel [...]

Authors: George PM, Wells AU, Jenkins RG PMID: 32422178 PMCID: PMC7228727 DOI: 10.1016/S2213-2600(20)30225-3 Abstract In December, 2019, reports emerged from Wuhan, China, of a severe acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). By the end of April, 2020, over 3 million people had been confirmed infected, with over 1 million [...]

Authors: Spagnolo P, Balestro E, Aliberti S, Cocconcelli E, Biondini D, Casa GD PMID: 32422177 PMCID: PMC7228737 DOI: 10.1016/S2213-2600(20)30222-8 Abstract As of May 6, 2020, nearly 3·7 million people have been infected and around 260 000 people have died from coronavirus disease 2019 (COVID-19) worldwide.1 Almost all COVID-19-related serious consequences feature pneumonia.2 In the first large [...]

Authors: Chiumello D, Cressoni M, Gattinoni L PMID: 32228035 PMCID: PMC7233352 DOI: 10.1164/rccm.202003-0817LE Abstract In northern Italy, an overwhelming number of patients with coronavirus disease (COVID-19) pneumonia and acute respiratory failure have been admitted to our ICUs. Attention is primarily focused on increasing the number of beds, ventilators, and intensivists brought to bear on the [...]

Authors: Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S PMID: 32416070 PMCID: PMC7227586 DOI: 10.1016/j.cell.2020.04.026 Abstract Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an [...]

The coronavirus, COVID-19, has infected hundreds of thousands and killed tens of thousands of individuals worldwide. This highly infectious condition continues to ravage the world population and has yet to reach it peak infective rate in some countries.

Authors: Chroboczek T, Lacoste M, Wackenheim C, Challan-Belval T, Amar B, Boisson T doi: https://doi.org/10.1101/2020.05.08.20094755 Abstract Background Since December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), responsible for Coronavirus Disease 2019 (COVID-19), is spreading worldwide, causing significant morbidity and mortality. No specific treatment has yet clearly shown to improve the disease’s evolution. Validated therapeutic [...]

Authors: Kurcicka L, Lauer SA, Laeyendecker O, Boon D, Lessler J PMID: 32422057 PMCID: PMC7240870 DOI: 10.7326/M20-1495 Abstract Background: Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on reverse transcriptase polymerase chain reaction (RT-PCR) are being used to rule out infection among high-risk persons, such as exposed inpatients and health care workers. It [...]