Authors: Prescott HC, Girard TD doi:10.1001/jama.2020.14103 Abstract As of July 30, 2020, more than 17 million people worldwide have been diagnosed with coronavirus disease 2019 (COVID-19), and more than 665 000 have died. In many countries, the rate of diagnosis continues to increase; for example, more than 50 000 new cases per day were reported in the [...]

Authors: Li L, Zhang W, Hu Y, Tong X, Zeng S, Yang J PMID: 32492084 PMCID: PMC7270883 DOI: 10.1001/jama.2020.10044 Abstract Importance: Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed. Objective: To evaluate the efficacy and adverse effects of convalescent plasma [...]

Authors: Morath C, Weigand MA, Zeier M, Speer C, Tiwari-Heckler S PMID: 32753056 PMCID: PMC7399583 DOI: 10.1186/s13054-020-03171-3 Abstract The spectrum of coronavirus disease 2019 (COVID-19) ranges from asymptomatic infection to respiratory failure and death of patients. Severely affected patients may develop a cytokine storm-like clinical syndrome with multi-organ failure and a mortality rate of up [...]

Auhtors: Andersson CR, Selvin T, Blom K, Rubin J, Berglund M, Jarvius M, et al. PMID: 32753665 PMCID: PMC7403428 DOI: 10.1038/s41598-020-68986-0 Abstract We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity in monocyte/macrophage models and induces ERK signalling. In the present study we investigated whether MBZ induced ERK activation is shared by [...]

Authors: Lu Y, Li X, Geng D, Mei N, Wu PY, Huang CC PMID: 32838240 PMCID: PMC7396952 DOI: 10.1016/j.eclinm.2020.100484 Abstract Background: Increasing evidence supported the possible neuro-invasion potential of SARS-CoV-2. However, no studies were conducted to explore the existence of the micro-structural changes in the central nervous system after infection. We [...]

Authors: Tobin MJ, Laghi F, Jubran A PMID: 32539537 PMCID: PMC7397783 DOI: 10.1164/rccm.202006-2157CP Abstract Patients with coronavirus disease (COVID-19) are described as exhibiting oxygen levels incompatible with life without dyspnea. The pairing-dubbed happy hypoxia but more precisely termed silent hypoxemia-is especially bewildering to physicians and is considered as defying basic biology. This combination has attracted [...]

Auhtors: Heiskanen V, Pfiffner M, Partonen T doi: https://doi.org/10.1016/j.arr.2020.101089 Abstract Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast [...]

Authors: Hiedra R, Lo KB, Elbashabsheh M, Gul F, Wright RM PMID: 32662690 PMCID: PMC7441798 DOI: 10.1080/14787210.2020.1794819 Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has affected almost 2.5 million people worldwide with almost 170,000 deaths reported to date. So far, there is scarce evidence for the current treatment options available for COVID-19. Vitamin C [...]

Authors: Cadegiani FA, Wambier CG, Goren A PMID: 32850920 PMCID: PMC7399048 DOI: 10.3389/fmed.2020.00453 Abstract At the onset of the COVID-19 pandemic, mortality following infection of severe acute respiratory coronavirus (SARS-CoV-2) was thought to be solely associated with aging and pre-existing conditions; however, as the pandemic ensued, several large scale epidemiological observations eluded to additional atypical [...]

Authors: Qin C, Zhou L, Hu Z, Zhang S PMID: 32161940 PMCID: PMC7108125 DOI: 10.1093/cid/ciaa248 Abstract Background: In December 2019, coronavirus 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China. Methods: Demographic and clinical data of all confirmed cases with COVID-19 on admission at Tongji Hospital from 10 January to 12 February 2020 were [...]