Authors: Kwon PS, Oh H, Kwon SJ, Jin W, Zhang F, Fraser K et al. PMID: 32714563 PMCID: PMC7378085 DOI: 10.1038/s41421-020-00192-8 Abstract COVID-19, caused by the SARS-CoV-2 virus, has now spread worldwide with catastrophic human and economic impacts and currently has infected over 10 million people and killed over 500,0001. In an effort to mitigate [...]

Paul S Kwon, Hanseul Oh, Seok-Joon Kwon, Weihua Jin, Fuming Zhang, Keith Fraser, Jung Joo Hong, Robert J Linhardt, Jonathan S Dordick PMID: 32714563 PMCID: PMC7378085 DOI: 10.1038/s41421-020-00192-8 Abstract No abstract available Keywords:Glycobiology; Mechanisms of disease. Source: https://pubmed.ncbi.nlm.nih.gov/32714563/ Archive: https://archive.is/wip/eUJkR

Authors: Varatharajah N doi: https://doi.org/10.20944/preprints202007.0516.v1 Abstract COVID-19 thromboembolic disease has brought all of us back to the drawing board. In COVID-19, pre-existing activated endothelium with increased Von Willebrand factor (VWF), low density lipoprotein (LDL) promoting “self-association” and “sticking” of long VWF strings to the vascular endothelial wall, suppressed ADAMTS13 cleavage of VWF, hypoxia induced upregulation [...]

Auhtors: Rainey NE, Moustapha A, Petit PX PMID: 32765806 PMCID: PMC7387956 DOI: 10.1155/2020/3656419 Abstract Curcumin has extensive therapeutic potential because of its antioxidant, anti-inflammatory, and antiproliferative properties. Multiple preclinical studies in vitro and in vivo have proven curcumin to be effective against various cancers. These potent effects are driven by curcumin's ability to induce G2/M [...]

Authors: Akbar AN, Gilroy DW PMID: 32675364 DOI: 10.1126/science.abb0762 Abstract Aging is associated with increased morbidity arising from a range of tissue dysfunctions. A common denominator of age-associated frailty is increased baseline inflammation, called inflammaging, that is present in older individuals. Recent studies have shown that the presence of excessive inflammation can inhibit immunity in [...]

Auhtors: Li C, Jiang P, Wei S, Xu X, Wang J PMID: 32680511 PMCID: PMC7367382 DOI: 10.1186/s12943-020-01234-1 Abstract Regulatory T cells (Tregs) characterized by the expression of the master transcription factor forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective immunosurveillance of tumours and hampering effective antitumour immune responses in tumour-bearing hosts, constitute [...]

Authors: Cadegiani FA, Goren A, Wambier CG PMID: 32721806 PMCID: PMC7363620 doi: 10.1016/j.mehy.2020.110112 Abstract In coronavirus disease-19 (COVID-19), four major factors have been correlated with worse prognosis: aging, hypertension, obesity, and exposure to androgen hormones. Angiotensin-converting enzyme-2 (ACE2) receptor, regulation of the renin-angiotensin-aldosterone system (RAAS), and transmembrane serine protease 2 (TMPRSS2) action are critical for [...]

Authors: Fontana F, Cazzato S, Giovanella S, Ballestri M, Leonelli M, Mori G PMID: 32838081 PMCID: PMC7363608 DOI: 10.1016/j.ekir.2020.07.008 Abstract Kidney dysfunction is frequently reported in patients with coronavirus disease 2019 (COVID-19). A recent large cohort study described an incidence of acute kidney injury (AKI) of 36% in patients who were hospitalized with COVID-19; AKI [...]

Auhtors: Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, Chytil A, et al. PMID: 20631080 PMCID: PMC4675145 DOI: 10.1158/0008-5472.CAN-10-0706 Abstract The mechanisms by which a primary tumor affects a selected distant organ before tumor cell arrival remain to be elucidated. This report shows that Gr-1+CD11b+ cells are significantly increased in lungs of mice [...]

Authors: Zhang J, Meng G, Li W, Shi B, Dong H, Su Z PMID: 32664991 PMCID: PMC7359422 DOI: 10.1186/s12931-020-01440-x Abstract Background: In December 2019, the outbreak of a disease subsequently termed COVID-19 occurred in Wuhan, China. The number of cases increased rapidly and spread to six continents. However, there is limited information on the chest [...]