Authors: Greenhalgh T, Knight M, A'Court C, Buxton M, Husain L PMID: 32784198 DOI: 10.1136/bmj.m3026 Abstract Post-acute covid-19 (“long covid”) seems to be a multisystem disease, sometimes occurring after a relatively mild acute illness.Clinical management requires a whole-patient perspective. This article, intended for primary care clinicians, relates to the patient who has a delayed recovery [...]

Authors: De Flora S, Balansky R, La Maestra S PMID: 32780893 PMCID: PMC7436914 DOI: 10.1096/fj.202001807 Abstract COVID-19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a systemic inflammatory response, and an attack by the immune system. Moreover, an oxidative stress imbalance has [...]

Vitamin D: modulator of the immune system. Current Opinion in Pharmacology 2010; 10:482-96. 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of vitamin D, is known to regulate calcium and phosphorus metabolism, thus being a key-player in bone-formation.

Authors:Carpagnano GE, Lecce V, Quaranta VN, Zito A, Buonamico E. PMID: PMC7415009 DOI: 10.1007/s40618-020-01370-x Abstract Purpose: Hypovitaminosis D is a highly spread condition correlated with increased risk of respiratory tract infections. Nowadays, the world is in the grip of the Coronavirus disease 19 (COVID 19) pandemic. In these patients, cytokine storm is associated with disease [...]

Authors: Shakoor H, Feehan J, Dhaheri AS, Ali HI, Platat C, Ismail LC PMID: 33308613 PMCID: PMC7415215 DOI: 10.1016/j.maturitas.2020.08.003 Abstract The world is currently in the grips of the coronavirus disease (COVID-19) pandemic, caused by the SARS-CoV-2 virus, which has mutated to allow human-to-human spread. Infection can cause fever, dry cough, fatigue, severe pneumonia, respiratory [...]

Authors: Marik PE, Stephenson E PMID: 32799183 DOI: 10.1016/j.jcrc.2020.07.026 Abstract Background: The global burden of death due to sepsis is considerable. Early diagnosis is essential to improve the outcome of this deadly syndrome. Yet, the diagnosis of sepsis is fraught with difficulties. Patients with blood stream infection (BSI) are at an increased risk of complications [...]

Authors: Gucyetmez B, Atalan HK, Sertdemir I, Cakir U, Telci L PMID: 32771054 PMCID: PMC7414262 DOI: 10.1186/s13054-020-03215-8 Abstract In patients with COVID-19 pneumonia, high risk of thrombosis became a current issue, and D-dimer levels indicating fibrin degradation products (FDPs) in the plasma were found as a predictor for mortality. Although unfractionated heparin (UFH) and low-molecular-weight [...]

Authors: Pujadas E, Chaudhry F, McBride R, Richter F, Zhao S PMID: 32771081 PMCID: PMC7836878 DOI: 10.1016/S2213-2600(20)30354-4 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection platforms currently report qualitative results. However, technology based on RT-PCR allows for calculation of viral load, which is associated with transmission risk and disease severity in other viral illnesses.1 [...]

Authors: Barrett TJ, Lee AH, Xia Y, Lin LH, Black M, Cotzia P PMID: 32757722 PMCID: PMC7478197 DOI: 10.1161/CIRCRESAHA.120.317803 Abstract The SARS-CoV-2 (SARS-CoV-2 severe acute respiratory syndrome coronavirus 2) coronavirus disease (COVID-19) is a global pandemic. Laboratory testing suggests a coagulopathy with up to 30% of hospitalized patients with COVID-19 developing thrombotic events.1 Platelets are [...]

Approximately 9 months of the severe acute respiratory syndrome coronavius-2 (SARS-CoV-2 [COVID-19]) spreading across the globe has led to widespread COVID-19 acute hospitalizations and death. The rapidity and highly communicable nature of the SARS-CoV-2 outbreak has hampered the design and execution of definitive randomized, controlled trials of therapy outside of the clinic or hospital.