Authors: Keith P, Wells AH, Hodges J, Fast SH PMID: 32831133 PMCID: PMC7443810 DOI: 10.1186/s13054-020-03241-6 Abstract Background: Sepsis remains a common condition with high mortality when multiple organ failure develops. The evidence for therapeutic plasma exchange (TPE) in this setting is promising but inconclusive. Our study aims to evaluate the efficacy of adjunct TPE for [...]

Konrad Kleszczyński, Andrzej T Slominski, Kerstin Steinbrink, Russel J Reiter PMID: 32847033 PMCID: PMC7551551 DOI: 10.3390/nu12092561 AbstractThe recent pandemic of COVID-19 has already infected millions of individuals and has resulted in the death of hundreds of thousands worldwide. Based on clinical features, pathology, and the pathogenesis of respiratory disorders induced by this and other highly [...]

Auhtors: Lopez P, Galvao DA, Taaffe DR, Newton RU, Souza G, Trajano GS, Pinto RS PMID: 32815096 DOI: 10.1007/s12282-020-01147-3 Abstract Background: Exercise is recognised as an adjunct therapy for breast cancer patients; however, little is known about the resistance training dose-response. We conducted a systematic review and meta-regression to examine the resistance training dose-response (i.e., [...]

Auhtors: Langade D, Thakare V, Kanchi S, Kelgane S PMID: 32818573 DOI: 10.1016/j.jep.2020.113276 Abstract Ethnopharmacological relevance: Ashwagandha (Withania somnifera (L.) Dunal.) is long known for its sleep-inducing effects. Ashwagandha can be proposed as an alternative to the recommended present treatments for insomnia. This study aimed to evaluate the pharmacological effect of Ashwagandha root extract on [...]

Authors: Mudatsir M, Yufika A, Nainu F, Frediansyah A, Megawati D doi: https://doi.org/10.3390/scipharm88030036 Abstract The coronavirus disease 2019 (COVID-19) pandemic is a major global threat. With no effective antiviral drugs, the repurposing of many currently available drugs has been considered. One such drug is ivermectin, an FDA-approved antiparasitic agent that has been shown to exhibit [...]

Authors: Abrams D, Lorusso R, Vincent JL, Brodie D PMID: 32807189 PMCID: PMC7429936 DOI: 10.1186/s13054-020-03230-9 Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to a critical shortage of resources in the hardest-hit areas around the world. Intensive care units (ICUs) overwhelmed by critically ill patients may create non-conventional ICU spaces and even consider triaging [...]

Authors: Shakoor H, Freehan J, Mikkelsen K, Al Dhaheri AS, Ali HI. PMID: 32829981 PMCID: PMC7428453 DOI: 10.1016/j.maturitas.2020.08.007 Abstract Coronavirus disease (COVID-19) is caused by the SARS-CoV-2 virus. In January 2020, the World Health Organization declared COVID-19 as a Public Health Emergency of International Concern and in March 2020, COVID-19 was characterized as a global [...]

Authors:Vergara-Buenaventura A, Castro-ruiz C. PMID: PMC7428696 DOI: 10.1016/j.bjoms.2020.08.016 Abstract The proximity to the patient during dental care, high generation of aerosols, and the identification of SARS-CoV-2 in saliva have suggested the oral cavity as a potential reservoir for COVID-19 transmission. Mouthwashes are widely-used solutions due to their ability to reduce the number of microorganisms in [...]

Authors: de Melo AF, Homem-de-Mello M PMID: 32792018 PMCID: PMC7424130 DOI: 10.1186/s13054-020-03228-3 Abstract The complete mechanism of action of the SARS-CoV-2 remains unclear. The severity of the disease is probably linked to the “cytokine storm” that leads to the acute respiratory distress syndrome. Cytokine storm is an overwhelming increase of several inflammatory markers at once, [...]

Authors: Tartof SY, Qian L, Hong V, Wei R, Nadjafi RF, Fischer H PMID: 32783686 PMCID: PMC7429998 DOI: 10.7326/M20-3742 Abstract Background: Obesity, race/ethnicity, and other correlated characteristics have emerged as high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)-associated outcomes, yet studies have not adequately disentangled their effects. Objective: To determine the adjusted effect of [...]