Authors: Kjellberg A, De Maio A, Lindholm P PMID: 33254531 PMCID: PMC7456590 DOI: 10.1016/j.mehy.2020.110224 Abstract Introduction: SARS-CoV-2 affects part of the innate immune response and activates an inflammatory cascade stimulating the release of cytokines and chemokines, particularly within the lung. Indeed, the inflammatory response during COVID-19 is likely the cause for the development of acute [...]

Authors: Ahmed AK, Albalawi YS, Shora HA, Abelseed HK, Al-Kattan AN. DOI:10.37179/rijed.000005 Abstract ABSTRACT COVID-19 emerged in Wuhan, China in December 2019, reached epidemic proportions and spread globally as a serious life-threatening pandemic. SARS- Cov-2 is the causative virus that causes severe acute respiratory distress, pneumonia, respiratory failure, and septic shock leading to increased mortality. [...]

Authors: Castillo ME, Costa LM, Barrios JM, Diaz JF, Miranda JL, Bouillon R et al. PMID: 32871238 PMCID: PMC7456194 DOI: 10.1016/j.jsbmb.2020.105751 Abstract Objective: The vitamin D endocrine system may have a variety of actions on cells and tissues involved in COVID-19 progression especially by decreasing the Acute Respiratory Distress Syndrome. Calcifediol can rapidly increase serum [...]

Authors: Le Balc'h P, Pinceaux K, Pronier C, Seguin P, Reizine F PMID: 32859241 PMCID: PMC7453668 DOI: 10.1186/s13054-020-03252-3 Abstract The SARS-CoV-2 infection can lead to severe acute respiratory distress syndrome (ARDS) with prolonged mechanical ventilation (MV). Patients with coronavirus disease 2019 (COVID-19) associated ARDS usually met the diagnosis criteria for sepsis-associated immunosuppression as acquired infections, [...]

Authors:Rizzoli R. PMID: PMC7897606 DOI: 10.1007/s40520-020-01678-x Abstract Vitamin D overdosing includes hypercalcemia, hypercalciuria, and mineral deposits in soft tissues. A safety upper limit of 4000 IU/day, which is consistently accepted, has been challenged, since the risk of adverse events in other systems than calcium-phosphate homeostasis may depend not only on the dose, [...]

Authors: Bortolotti D, Gentili V, Rizzo S, Rotola A, Rizzo R PMID: 32859121 PMCID: PMC7563485 DOI: 10.3390/cells9091975 Abstract Natural killer cells are important in the control of viral infections. However, the role of NK cells during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has previously not been identified. Peripheral blood NK cells from SARS-CoV [...]

Authors: Buijsers B, Yanginlar C, Maciej-Hulme ML, de Mast Q PMID: 32853989 PMCID: PMC7445140 DOI: 10.1016/j.ebiom.2020.102969 Abstract Coronavirus disease-2019 (COVID-19) is associated with severe inflammation in mainly the lung, and kidney. Reports suggest a beneficial effect of the use of heparin/low molecular weight heparin (LMWH) on mortality in COVID-19. In part, this beneficial effect could [...]

Authors: Vatsalya V, Li F, Frimodig J, Gala KS, Srivastava S, Kong M PMID: 32869036 PMCID: PMC7457607 DOI: 10.1101/2020.08.23.20177501 Abstract Introduction Emerging infectious diseases, especially the coronavirus disease identified in 2019 (COVID-19), can be complicated by a severe exacerbation in the Th17 cell-mediated IL-17 proinflammatory immune storm. This enhanced immune response plays a major role [...]

Authors: Cypel M, Keshavjee S PMID: 32857989 PMCID: PMC7447224 DOI: 10.1016/S2213-2600(20)30393-3 Abstract Several respiratory viruses are known to cause acute respiratory distress syndrome (ARDS). Survival and lung recovery rates are well known for influenza viruses; however, ARDS related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has posed an unprecedented challenge. Lung transplantation has [...]

Authors: Ghosh I, Sankhe R, Mudgal J, Arora D, Nampoothiri M PMID: 32873420 DOI: 10.1016/j.npep.2020.102083 Abstract Spermidine is a naturally occurring endogenous polyamine synthesized from diamine putrescine. It is a well-known autophagy inducer that maintains cellular and neuronal homeostasis. Healthy brain development and function are dependent on brain polyamine concentration. Polyamines interact with the opioid [...]