Auhtors: Cheng WY, Wu CY, Yu J doi: https://doi.org/10.1136/gutjnl-2020-321153 Abstract The gut microbiota has been implicated in cancer and shown to modulate anticancer drug efficacy. Altered gut microbiota is associated with resistance to chemo drugs or immune checkpoint inhibitors (ICIs), whereas supplementation of distinct bacterial species restores responses to the anticancer drugs. Accumulating evidence has [...]

Authors: DiNicolantonio JJ, Barroso-Arranda J, McCarty M PMID: 32895293 PMCID: PMC7476419 DOI: 10.1136/openhrt-2020-001350 Abstract Ivermectin, on the WHO’s List of Essential Medications, has been in clinical use since 1981 as an orally and topically active agent for treating a range of parasitic infections in humans, including river blindness and lymphatic filariasis. It is also widely [...]

Conclusions: The results of this case series suggest that high-dose oral famotidine is well tolerated and associated with improved patient-reported outcomes in non-hospitalised patients with COVID-19.

Daniel E Freedberg, Joseph Conigliaro, Timothy C Wang, Kevin J Tracey, Michael V Callahan, Julian A Abrams, Famotidine Research Group PMID: 32446698 PMCID: PMC7242191 DOI: 10.1053/j.gastro.2020.05.053 AbstractNo abstract available. Keywords: Histamine H2 Antagonists, Famotidine Source: https://pubmed.ncbi.nlm.nih.gov/32446698/ Archive: https://archive.is/wip/xU10m

Authors: Zhang S, Liu Y, Wang X, Yang L, Li H, Wang Y PMID: 32887634 PMCID: PMC7471641 DOI: 10.1186/s13045-020-00954-7 Abstract Background: Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events [...]

Authors: Karst M, Hollenhorst J, Achenbach J PMID: 33254541 PMCID: PMC7467063 DOI: 10.1016/j.mehy.2020.110234 Abstract As the current COVID-19 pandemic develops and epidemiological data reveals differences in geographical spread as well as risk factors for developing a severe course of illness, hypotheses regarding possible underlying mechanisms need to be developed and tested. In our hypothesis, we [...]

Authors: van Eeden C, Khqn L, Osman MS, Tevaert JW PMID: 32883007 PMCID: PMC7503862 DOI: 10.3390/ijms21176351 Abstract When facing an acute viral infection, our immune systems need to function with finite precision to enable the elimination of the pathogen, whilst protecting our bodies from immune-related damage. In many instances however this "perfect balance" is not [...]

Authors: Cheng HY, Jian SW, Liu DP, Huang WT, Lin HH PMID: 32356867 PMCID: PMC7195694 DOI: 10.1001/jamainternmed.2020.2020 Abstract Importance: The dynamics of coronavirus disease 2019 (COVID-19) transmissibility are yet to be fully understood. Better understanding of the transmission dynamics is important for the development and evaluation of effective control policies. Objective: To delineate the transmission [...]

Authors: Chen JJ, Zeng BS, Wu CN, Stubbs B, Carvalho AF, Su KP PMID: 32644131 PMCID: PMC7349076 DOI: 10.1001/jamaoto.2020.1497 Abstract Importance: Tinnitus has a prevalence of 10% to 25% and is frequently associated with numerous complications, such as neuropsychiatric disease. Traditional treatments have failed to meet the needs of patients with tinnitus. Noninvasive brain stimulation [...]

Authors: Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM PMID: 32702719 PMCID: PMC7336703 doi: 10.21203/rs.3.rs-30934/v3 Abstract SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. Currently, there are no pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine [...]