Authors: Shodell M, Siegal FP PMID: 11544466 DOI: 10.1067/mai.2001.117928 Abstract Glucocorticoids are strongly immunosuppressive and are associated with reactivation of some intracellular infections. The plasmacytoid dendritic cell is a rare blood mononuclear cell detected through its production of IFN-alpha in response to herpes simplex virus and by surface immunophenotyping. We here report that steroid administration [...]

Authors: Hartter S, Wang X, Weigmann H, Friedberg T, Arand M PMID: 11270913 DOI: 10.1097/00004714-200104000-00008 Abstract Melatonin, the predominant product of the pineal gland, is involved in the maintenance of diurnal rhythms. Nocturnal blood concentrations of melatonin have been shown to be enhanced by fluvoxamine, but not by other serotonin reuptake inhibitors. Because fluvoxamine is [...]

Auhtors: Ayre SG, Bellon DP, Garcia DP, Jr. PMID: 11000062 DOI: 10.1054/mehy.2000.1063 Abstract The endogenous molecular biology of cancer cells involves autocrine and paracrine secretion of insulin and insulin-like growth-factors I and II, which subserve energy production and growth stimulation, respectively, in these cells. These activities confer on cancer its malignant potential, working as they [...]

Authors: Javors MA, Houston JP, Tekell JL, Brannan SK, Frazer A PMID: 11343600 DOI: 10.1017/S146114570000198X Abstract Drugs thought to be selective inhibitors of either the uptake of serotonin (5-HT) or norepinephrine (NE) are known to be effective antidepressants. In general, a relative selectivity for NE vs. 5-HT uptake inhibition greater than 50-fold in vitro is [...]

Authors: MacLean MR, Herve P, Eddahibi S, Adnot S PMID: 10991906 PMCID: PMC1572323 DOI: 10.1038/sj.bjp.0703570 Abstract Circulating 5-hydroxytryptamine (5-HT) is produced mainly in the enterochromaffin cells of the intestine. 5-HT is also, however, locally released from pulmonary neuroendocrine cells and neuroepithelial bodies distributed throughout the airways. Secretion of large amounts of 5-HT from these cells [...]

Auhtors: McCarty OJ, Mousa SA, Bray PF, Konstantopoulos K PMID: 10961878 Abstract Accumulating evidence suggests that successful metastatic spread may depend on the ability of tumor cells to undergo extensive interactions with platelets. However, the mechanisms mediating tumor cell adhesion to platelets under conditions of flow remain largely unknown. Therefore, this study was designed to [...]

Authors: Mashour S, Turner JF, Merrell R PMID: 10936161 DOI: 10.1378/chest.118.2.561 Abstract With the increased use of nonprescription vitamin supplementation, physicians involved in critical care must be aware of the potential complications of these medications. We report the case of a 31-year-old African-American man presenting to the emergency department with acute renal failure. He had [...]

Auhtors: Westerdahl J, Ingvar C, Mâsbäck A, Olsson H PMID: 10861466 DOI: 10.1002/1097-0215(20000701)87:13.0.co;2-3 Abstract In a new population-based, matched, case-control study from southern Sweden of 571 patients with a first diagnosis of cutaneous malignant melanoma, between 1995 and 1997, and 913 healthy controls aged 16 to 80 years, the association between sunscreen use and malignant [...]

Auhtors: Yokota J PMID: 10688870 DOI: 10.1093/carcin/21.3.497 Abstract It is now widely accepted that cancer is attributed to the accumulation of genetic alterations in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is indispensable to identify the genes whose alterations accumulate during cancer progression as well as the genes whose expression is [...]

Auhtors: Hanahan D, Weinberg RA DOI:https://doi.org/10.1016/S0092-8674(00)81683-9 Abstract After a quarter century of rapid advances, cancer research has generated a rich and complex body of knowledge, revealing cancer to be a disease involving dynamic changes in the genome. The foundation has been set in the discovery of mutations that produce oncogenes with dominant gain of function [...]