Authors: Chandra AK, De N. PMID: 23117228 DOI: 10.1007/s11010-012-1503-8 Abstract Catechins, the flavonoids found in abundance in green tea, have many beneficial health effects such as antioxidative, anticarcinogenic, anti-inflammatory, antiallergic, and hypotensive properties. However, flavonoids have antithyroid/goitrogenic effect, although less information is available about the effect of pure catechin on thyroid physiology. The present investigation [...]

Safety and pharmacokinetics (PK) of the antiparasitic drug ivermectin, administered in higher and/or more frequent doses than currently approved for human use, were evaluated in a double-blind, placebo-controlled, dose escalation study.

Auhtors: Nowell PC PMID: 12147207 DOI: 10.1016/s1044-579x(02)00012-3 Abstract It has long been known that tumors become more clinically and biologically aggressive over time. This has been termed 'tumor progression' and includes, among other properties invasion and metastasis, as well as more efficient escape from host immune regulation. Since 1960, first cytogenetics and then molecular techniques [...]

Authors: Busund R, Koukline V, Utrobin U, Nedashkovsky E PMID: 12373468 DOI: 10.1007/s00134-002-1410-7 Abstract Objective: To determine the therapeutic efficacy and safety of plasmapheresis in the treatment of patients with severe sepsis and septic shock. Design: Prospective, randomised, clinical trial with a planned, midstudy, interim analysis. Setting: Intensive care unit in a university hospital in [...]

Authors: Shiraishi T, Nakagawa Y. PMID: 12011519 DOI: 10.1159/000057723 AbstractObjective: Encouragement of gargling is important for the control of opportunistic and community-acquired infections. In hospitals, a povidone-iodine (PVP-I) gargle is used frequently. However, at pharmacies in the community a variety of gargles containing various ingredients are now available. In view of this, we conducted a [...]

Authors: Ichikado K, Suga M, Muller NL, Tangiguchi H, Kondoh Y, Akira M PMID: 12045132 DOI: 10.1164/rccm.2106157 Abstract This study compared high-resolution computed tomography (CT) findings between 10 survivors and 21 nonsurvivors of acute interstitial pneumonia and evaluated whether the CT findings were predictive of patients' response to treatment. The survivor and nonsurvivor groups with [...]

Auhtors: Klimp AH, Hollema H, Kempinga C, van der Zee AG, de Vries EG, Daemen T PMID: 11585770 Abstract This study investigates whether and to what extent cyclooxygenase type-2 (COX-2) and inducible nitric oxide-synthase (iNOS), both known to have an immunosuppressive effect, are expressed in human ovarian tumors. Because COX-2 and iNOS can be expressed [...]

Auhtors: John AP PMID: 11601863 DOI: 10.1054/mehy.2001.1335 Abstract It has been known for decades that cancer cells produce excessive amounts of lactic acid. The fact that most cancers have poor vascular systems has led cancer scientists to assume that such cells are deprived of a normal supply of oxygen. Researchers believe that without sufficient oxygen, [...]

Authors: Bayar N, Boke B, Turan E, Belgin E PMID: 11771024 DOI: 10.2310/7070.2001.19597 Abstract We investigated the effect of amitriptyline, a tricyclic antidepressant, on patients with subjective tinnitus. The study group consisted of 37 adult patients admitted to the Ear, Nose, and Throat and Audiology Department of Hacettepe University. The amitriptyline group consisted of 20 [...]

M Shodell 1, F P Siegal PMID: 11544466 DOI: 10.1067/mai.2001.117928 Abstract Glucocorticoids are strongly immunosuppressive and are associated with reactivation of some intracellular infections. The plasmacytoid dendritic cell is a rare blood mononuclear cell detected through its production of IFN-alpha in response to herpes simplex virus and by surface immunophenotyping. We here report that [...]