Authors: Maurer-Spurej E, Pittendreigh C, Solomons K PMID: 14691577 DOI: 10.1160/TH03-05-0330 Abstract Clinical depression has been proposed to be an independent risk factor for cardiovascular disease. While it is suggested that selective serotonin reuptake inhibitors (SSRIs) reduce the risk of acute cardiovascular problems of depressed patients, the effect of SSRIs on platelets, the only blood [...]

Auhtors: Lasalvia-Prisco E, Cucchi S, Vázquez J, Lasalvia-Galante E, Golomar W, Gordon W. PMID: 14655024 DOI: 10.1007/s00280-003-0716-7 Abstract Purpose: It has been reported that insulin increases the cytotoxic effect in vitro of methotrexate by as much as 10,000-fold. The purpose of this study was to explore the clinical value of insulin as a potentiator of [...]

Authors: Edwards G PMID: 14975065 PMCID: PMC2147658 DOI: 10.1186/1475-2883-2-S1-S8 Abstract The macrocyclic lactone ivermectin (Mectizan(R)) is widely used for the control of human filarial infections, particularly as a donated product for onchocerciasis and lymphatic filariasis. In the case of control of lymphatic filariasis in Africa, it is used in combination with donated albendazole. In areas [...]

Auhtors: Alaee M, Arias P, Sjödin A, Bergman A PMID: 12850087 DOI: 10.1016/S0160-4120(03)00121-1 Abstract Brominated flame retardants (BFRs) are used in a variety of consumer products and several of those are produced in large quantities. These compounds have been detected in environmental samples, which can be attributed to the anthropogenic uses of these compounds. Brominated [...]

Auhtors: Li L, Connelly MC, Wetmore C, Curran T, Morgan JI PMID: 12782575 Abstract Cancer cells escape from growth control by accumulating genetic and epigenetic alterations. In rare instances, epigenetic changes alone are oncogenic. Furthermore, agents that modify DNA methylation or chromatin structure can restore a normal phenotype to cells harboring oncogenic mutations. However, it [...]

Auhtors: Li C, Allen A, Kwagh J, Doliba NM, Qin W, Najafi H, et al. PMID: 16476731 DOI: 10.1074/jbc.M512792200 Abstract Insulin secretion by pancreatic beta-cells is stimulated by glucose, amino acids, and other metabolic fuels. Glutamate dehydrogenase (GDH) has been shown to play a regulatory role in this process. The importance of GDH was underscored [...]

Authors: Nair MP, Kandaswami C, Mahajan S, Chadha KC, Chawda R, Nair H. PMID: 12431781 DOI: 10.1016/s0167-4889(02)00328-2 Abstract Flavonoids are plant metabolites that are dietary antioxidants and exert significant anti-tumor, anti-allergic, anti-inflammatory and anti-viral effects. It is generally accepted that Th-1 derived cytokines such as IL-2, IFNgamma and IL-12 promote cellular immunity while Th-2 derived [...]

Authors: Pan H, Peto R, Karim QA, Alejandria M, Henao-Restrepo AM PMID: 33264556 PMCID: PMC7727327 DOI: 10.1056/NEJMoa2023184 Abstract Background: World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with coronavirus disease 2019 (Covid-19). Methods: We randomly assigned inpatients with Covid-19 [...]

Auhtors: Guezva JM, Krajewska M, de Heredia ML, Krajewski S, Santamaria G, Kim H, et al. PMID: 12438266 Abstract Mitochondrial H+-ATP synthase is required for cellular energy provision and for efficient execution of apoptosis. Almost one century ago, Otto Warburg proposed the hypothesis that mitochondrial function might be impaired in cancer cells. However, his hypothesis [...]

Auhtors: Delsite R, Kachhap S, Anbazhagan R, Gabrielson E, Singh KK PMID: 12495447 PMCID: PMC149409 DOI: 10.1186/1476-4598-1-6 Abstract Background: The interaction of nuclear and mitochondrial genes is an essential feature in maintenance of normal cellular function. Of 82 structural subunits that make up the oxidative phosphorylation system in the mitochondria, mitochondrial DNA (mtDNA) encodes 13 [...]