Auhtors: Labelle M, Begum S, Hynes RO PMID: 22094253 PMCID: PMC3487108 DOI: 10.1016/j.ccr.2011.09.009 Abstract Interactions of cancer cells with the primary tumor microenvironment are important determinants of cancer progression toward metastasis but it is unknown whether additional prometastatic signals are provided during the intravascular transit to the site of metastasis. Here, we show that platelet-tumor [...]

Auhtors: Bin YS, Marshall NS, Glozier N PMID: 22075214 DOI: 10.1016/j.smrv.2011.07.003 Abstract Objectives: Little evidence exists to support the common assertion that adult sleep duration has declined. We investigated secular trends in sleep duration over the past 40 years through a systematic review. Methods: Systematic search of 5 electronic databases was conducted to identify repeat [...]

Authors: Wu C, Li A, Leng Y, Kang J PMID: 22054065 DOI: 10.1089/dna.2011.1401 Abstract Recent studies suggest that change of macrophage phenotype (M1/M2) is associated with autoimmune diseases. Sodium valproate (VPA) is a class I histone deacetylase (HDAC) inhibitor, which has immunomodulatory function in graft-versus-host disease. However, its impact on macrophage polarization has not been [...]

Auhtors: Li M, Li C, Allen A, Stanley CA, Smith TJ PMID: 22079166 PMCID: PMC3294041 DOI: 10.1016/j.abb.2011.10.015 Abstract Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of l-glutamate to 2-oxoglutarate. Only in the animal kingdom is this enzyme heavily allosterically regulated by a wide array of metabolites. The major activators [...]

Authors: Wikramanayake TC, Villasante AC, Mauro LM, Perez CI, Jimenez JJ PMID: 22042611 PMCID: PMC3273564 DOI: 10.1007/s12192-011-0305-3 Abstract Alopecia areata (AA) is an autoimmune non-scarring hair loss disorder. AA can be acute, recurrent, or chronic. Current therapeutic options for AA are limited, and there is no effective prevention for recurrent AA. We have previously shown [...]

Auhtors: Chen Q, Zhang XH, Massagu J PMID: 22014578 PMCID: PMC3293160 DOI: 10.1016/j.ccr.2011.08.025 Abstract Aberrant expression of vascular cell adhesion molecule-1 (VCAM-1) in breast cancer cells is associated with lung relapse, but the role of VCAM-1 as a mediator of metastasis has remained unknown. We report that VCAM-1 provides a survival advantage to breast cancer [...]

Authors: Titos E, Rius B, Gonzalez-Periz A, Lopez-Vicario C, Arroyo V, Claria J PMID: 22013115 DOI: 10.4049/jimmunol.1100225 Abstract We recently demonstrated that ω-3-polyunsaturated fatty acids ameliorate obesity-induced adipose tissue inflammation and insulin resistance. In this study, we report novel mechanisms underlying ω-3-polyunsaturated fatty acid actions on adipose tissue, adipocytes, and stromal vascular cells (SVC). [...]

Auhtors: Murray PJ, Wynn TA PMID: 21997792 PMCID: PMC3422549 DOI: 10.1038/nri3073 Abstract Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals. They are highly heterogeneous cells that can rapidly change their function in response to local [...]

Auhtors: Chequer FM, Dorta DJ, Oliveira DP DOI:10.5772/19872 Abstract Colorants (dyes and pigments) are important industrial chemicals. According to the technological nomenclature, pigments are colorants which are insoluble in the medium to which they are added, whereas dyes are soluble in the medium. The world’s first commercially successful synthetic dye, named mauveine, was discovered by [...]

Auhtors: Beasley JM, Kwan ML, Chen WY, Weltzien EK, Kroenke CH, Lu W, et al. PMID: 21935600 PMCID: PMC3272362 DOI: 10.1007/s10549-011-1770-1 Abstract The 2008 Physical Activity (PA) Guidelines recommend engaging in at least 2.5 h (10 MET-hours/week) of moderate intensity PA per week (defined as 4 METs) to reduce risk of morbidity and mortality. This [...]