Authors: Le Balc'h P, Pinceaux K, Pronier C, Seguin P, Reizine F PMID: 32859241 PMCID: PMC7453668 DOI: 10.1186/s13054-020-03252-3 Abstract The SARS-CoV-2 infection can lead to severe acute respiratory distress syndrome (ARDS) with prolonged mechanical ventilation (MV). Patients with coronavirus disease 2019 (COVID-19) associated ARDS usually met the diagnosis criteria for sepsis-associated immunosuppression as acquired infections, [...]

Authors: Buijsers B, Yanginlar C, Maciej-Hulme ML, de Mast Q PMID: 32853989 PMCID: PMC7445140 DOI: 10.1016/j.ebiom.2020.102969 Abstract Coronavirus disease-2019 (COVID-19) is associated with severe inflammation in mainly the lung, and kidney. Reports suggest a beneficial effect of the use of heparin/low molecular weight heparin (LMWH) on mortality in COVID-19. In part, this beneficial effect could [...]

Authors: Vatsalya V, Li F, Frimodig J, Gala KS, Srivastava S, Kong M PMID: 32869036 PMCID: PMC7457607 DOI: 10.1101/2020.08.23.20177501 Abstract Introduction Emerging infectious diseases, especially the coronavirus disease identified in 2019 (COVID-19), can be complicated by a severe exacerbation in the Th17 cell-mediated IL-17 proinflammatory immune storm. This enhanced immune response plays a major role [...]

Authors: Cypel M, Keshavjee S PMID: 32857989 PMCID: PMC7447224 DOI: 10.1016/S2213-2600(20)30393-3 Abstract Several respiratory viruses are known to cause acute respiratory distress syndrome (ARDS). Survival and lung recovery rates are well known for influenza viruses; however, ARDS related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has posed an unprecedented challenge. Lung transplantation has [...]

Authors: Mudatsir M, Yufika A, Nainu F, Frediansyah A, Megawati D doi: https://doi.org/10.3390/scipharm88030036 Abstract The coronavirus disease 2019 (COVID-19) pandemic is a major global threat. With no effective antiviral drugs, the repurposing of many currently available drugs has been considered. One such drug is ivermectin, an FDA-approved antiparasitic agent that has been shown to exhibit [...]

Authors: Abrams D, Lorusso R, Vincent JL, Brodie D PMID: 32807189 PMCID: PMC7429936 DOI: 10.1186/s13054-020-03230-9 Abstract The coronavirus disease 2019 (COVID-19) pandemic has led to a critical shortage of resources in the hardest-hit areas around the world. Intensive care units (ICUs) overwhelmed by critically ill patients may create non-conventional ICU spaces and even consider triaging [...]

Authors: de Melo AF, Homem-de-Mello M PMID: 32792018 PMCID: PMC7424130 DOI: 10.1186/s13054-020-03228-3 Abstract The complete mechanism of action of the SARS-CoV-2 remains unclear. The severity of the disease is probably linked to the “cytokine storm” that leads to the acute respiratory distress syndrome. Cytokine storm is an overwhelming increase of several inflammatory markers at once, [...]

Authors: Tartof SY, Qian L, Hong V, Wei R, Nadjafi RF, Fischer H PMID: 32783686 PMCID: PMC7429998 DOI: 10.7326/M20-3742 Abstract Background: Obesity, race/ethnicity, and other correlated characteristics have emerged as high-profile risk factors for adverse coronavirus disease 2019 (COVID-19)-associated outcomes, yet studies have not adequately disentangled their effects. Objective: To determine the adjusted effect of [...]

Authors: De Flora S, Balansky R, La Maestra S PMID: 32780893 PMCID: PMC7436914 DOI: 10.1096/fj.202001807 Abstract COVID-19 may cause pneumonia, acute respiratory distress syndrome, cardiovascular alterations, and multiple organ failure, which have been ascribed to a cytokine storm, a systemic inflammatory response, and an attack by the immune system. Moreover, an oxidative stress imbalance has [...]

Authors: Gucyetmez B, Atalan HK, Sertdemir I, Cakir U, Telci L PMID: 32771054 PMCID: PMC7414262 DOI: 10.1186/s13054-020-03215-8 Abstract In patients with COVID-19 pneumonia, high risk of thrombosis became a current issue, and D-dimer levels indicating fibrin degradation products (FDPs) in the plasma were found as a predictor for mortality. Although unfractionated heparin (UFH) and low-molecular-weight [...]