Authors: Tan CW, Ho LP, Kalimuddin S, Cherng BP, Teh YE PMID: 33039952 PMCID: PMC7832811 DOI: 10.1016/j.nut.2020.111017 Abstract Objectives: The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B12 (DMB) compared with those who did not. We hypothesized [...]

Authors: DiNicolantonio JJ, Barroso-Arranda J, McCarty M PMID: 32895293 PMCID: PMC7476419 DOI: 10.1136/openhrt-2020-001350 Abstract Ivermectin, on the WHO’s List of Essential Medications, has been in clinical use since 1981 as an orally and topically active agent for treating a range of parasitic infections in humans, including river blindness and lymphatic filariasis. It is also widely [...]

Conclusions: The results of this case series suggest that high-dose oral famotidine is well tolerated and associated with improved patient-reported outcomes in non-hospitalised patients with COVID-19.

Authors: Zhang S, Liu Y, Wang X, Yang L, Li H, Wang Y PMID: 32887634 PMCID: PMC7471641 DOI: 10.1186/s13045-020-00954-7 Abstract Background: Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events [...]

Authors: Karst M, Hollenhorst J, Achenbach J PMID: 33254541 PMCID: PMC7467063 DOI: 10.1016/j.mehy.2020.110234 Abstract As the current COVID-19 pandemic develops and epidemiological data reveals differences in geographical spread as well as risk factors for developing a severe course of illness, hypotheses regarding possible underlying mechanisms need to be developed and tested. In our hypothesis, we [...]

Authors: van Eeden C, Khqn L, Osman MS, Tevaert JW PMID: 32883007 PMCID: PMC7503862 DOI: 10.3390/ijms21176351 Abstract When facing an acute viral infection, our immune systems need to function with finite precision to enable the elimination of the pathogen, whilst protecting our bodies from immune-related damage. In many instances however this "perfect balance" is not [...]

Authors: Cheng HY, Jian SW, Liu DP, Huang WT, Lin HH PMID: 32356867 PMCID: PMC7195694 DOI: 10.1001/jamainternmed.2020.2020 Abstract Importance: The dynamics of coronavirus disease 2019 (COVID-19) transmissibility are yet to be fully understood. Better understanding of the transmission dynamics is important for the development and evaluation of effective control policies. Objective: To delineate the transmission [...]

Authors: Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM PMID: 32702719 PMCID: PMC7336703 doi: 10.21203/rs.3.rs-30934/v3 Abstract SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. Currently, there are no pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine [...]

Authors: Kjellberg A, De Maio A, Lindholm P PMID: 33254531 PMCID: PMC7456590 DOI: 10.1016/j.mehy.2020.110224 Abstract Introduction: SARS-CoV-2 affects part of the innate immune response and activates an inflammatory cascade stimulating the release of cytokines and chemokines, particularly within the lung. Indeed, the inflammatory response during COVID-19 is likely the cause for the development of acute [...]

Authors: Castillo ME, Costa LM, Barrios JM, Diaz JF, Miranda JL, Bouillon R et al. PMID: 32871238 PMCID: PMC7456194 DOI: 10.1016/j.jsbmb.2020.105751 Abstract Objective: The vitamin D endocrine system may have a variety of actions on cells and tissues involved in COVID-19 progression especially by decreasing the Acute Respiratory Distress Syndrome. Calcifediol can rapidly increase serum [...]