Authors: Andreakos E, Papadaki M, Serhan CN PMID: 32956495 PMCID: PMC7537007 DOI: 10.1111/all.14595 Abstract Coronavirus disease-19 (COVID-19) is a new disease caused by SARS-CoV-2. Since the beginning of 2020, it has become one of the main challenges of our times, causing a high incidence of severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan failure, and [...]

Auhtors: Hope JR Abstract How does a trained physician beat terminal cancer when he, himself, gets it? · The answer will both shock and surprise you, as it is often NOT the same treatment that physicians prescribe for their patients. · Dr.Hope takes you through successful survival stories of doctor after doctor -and he explains [...]

Authors: Arvinte C, Singh M, Marik PE PMID: 32964205 PMCID: PMC7499070 DOI: 10.1016/j.medidd.2020.100064 Abstract Background: The COVID-19 pandemic has placed an enormous and growing burden on the population and health infrastructure, warranting innovative ways to mitigate risk of contracting and developing severe forms of this disease. A growing body of literature raises the issue of [...]

Authors: Zaid Y, Puhm F, Allaeys I, Naya A, Oudghiri M PMID: 32938299 PMCID: PMC7641188 DOI: 10.1161/CIRCRESAHA.120.317703 Abstract Rationale: In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute to the lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Platelets are chiefly implicated in thrombosis. Moreover, [...]

Authors: Salton F, Confalonieri P, Santus P, Harari S, Scala R, Lanini S et al. PMID: 33072814 PMCID: PMC7543560 DOI: 10.1093/ofid/ofaa421 Abstract Background: In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated with significant morbidity and mortality. Severe dysregulated systemic inflammation is the [...]

Authors: Han AY, Mukdad L, Long JL, Lopez IA PMID: 32914699 PMCID: PMC7488171 DOI: 10.1177/1073858420956905 Abstract In recent months it has emerged that the novel coronavirus-responsible for the COVID-19 pandemic-causes reduction of smell and taste in a large fraction of patients. The chemosensory deficits are often the earliest, and sometimes the only signs in otherwise [...]

Authors: Hottz ED, Azevedo-Quintanilha Ig, Palhinha L, Teixeira L, Barreto EA PMID: 32678428 PMCID: PMC7483437 DOI: 10.1182/blood.2020007252 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emergent pathogen responsible for the coronavirus disease 2019 (COVID-19). Since its emergence, the novel coronavirus has rapidly achieved pandemic proportions causing remarkably increased morbidity and mortality around the [...]

Authors: Afrin LB, Weinstock LB, Molderings GJ PMID: 32920235 PMCID: PMC7529115 DOI: 10.1016/j.ijid.2020.09.016 Abstract Objectives: One-fifth of Covid-19 patients suffer a severe course of Covid-19 infection; however, the specific causes remain unclear. Mast cells (MCs) are activated by SARS-CoV-2. Although only recently recognized, MC activation syndrome (MCAS), usually due to acquired MC clonality, is a [...]

Authors: Bassetti M, Kollef MH, Timsit JF PMID: 32902729 PMCID: PMC7479998 DOI: 10.1007/s00134-020-06219-8 Abstract Are critically ill patients with coronavirus disease 2019 (COVID-19) at high risk of bacterial and fungal superinfections developing on the top of the viral infection in the lung or in other body sites? And from which organisms? Answering these apparently simple [...]

Authors: Hekimian G, Kerneis M, Zeitouni M, Cohen-Aubart F, Chommeloux J PMID: 32910974 PMCID: PMC7476896 DOI: 10.1016/j.chest.2020.08.2099 Abstract Hyperinflammatory shock was described recently in children during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The clinical presentation of these patients involved fever, cutaneous rash, abdominal symptoms, distributive shock, and acute cardiac injury. This multisystem [...]