Authors: Pujadas E, Chaudhry F, McBride R, Richter F, Zhao S PMID: 32771081 PMCID: PMC7836878 DOI: 10.1016/S2213-2600(20)30354-4 Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection platforms currently report qualitative results. However, technology based on RT-PCR allows for calculation of viral load, which is associated with transmission risk and disease severity in other viral illnesses.1 [...]

Authors: Barrett TJ, Lee AH, Xia Y, Lin LH, Black M, Cotzia P PMID: 32757722 PMCID: PMC7478197 DOI: 10.1161/CIRCRESAHA.120.317803 Abstract The SARS-CoV-2 (SARS-CoV-2 severe acute respiratory syndrome coronavirus 2) coronavirus disease (COVID-19) is a global pandemic. Laboratory testing suggests a coagulopathy with up to 30% of hospitalized patients with COVID-19 developing thrombotic events.1 Platelets are [...]

Approximately 9 months of the severe acute respiratory syndrome coronavius-2 (SARS-CoV-2 [COVID-19]) spreading across the globe has led to widespread COVID-19 acute hospitalizations and death. The rapidity and highly communicable nature of the SARS-CoV-2 outbreak has hampered the design and execution of definitive randomized, controlled trials of therapy outside of the clinic or hospital.

Authors: Prescott HC, Girard TD doi:10.1001/jama.2020.14103 Abstract As of July 30, 2020, more than 17 million people worldwide have been diagnosed with coronavirus disease 2019 (COVID-19), and more than 665 000 have died. In many countries, the rate of diagnosis continues to increase; for example, more than 50 000 new cases per day were reported in the [...]

Authors: Li L, Zhang W, Hu Y, Tong X, Zeng S, Yang J PMID: 32492084 PMCID: PMC7270883 DOI: 10.1001/jama.2020.10044 Abstract Importance: Convalescent plasma is a potential therapeutic option for patients with coronavirus disease 2019 (COVID-19), but further data from randomized clinical trials are needed. Objective: To evaluate the efficacy and adverse effects of convalescent plasma [...]

Authors: Morath C, Weigand MA, Zeier M, Speer C, Tiwari-Heckler S PMID: 32753056 PMCID: PMC7399583 DOI: 10.1186/s13054-020-03171-3 Abstract The spectrum of coronavirus disease 2019 (COVID-19) ranges from asymptomatic infection to respiratory failure and death of patients. Severely affected patients may develop a cytokine storm-like clinical syndrome with multi-organ failure and a mortality rate of up [...]

Authors: Lu Y, Li X, Geng D, Mei N, Wu PY, Huang CC PMID: 32838240 PMCID: PMC7396952 DOI: 10.1016/j.eclinm.2020.100484 Abstract Background: Increasing evidence supported the possible neuro-invasion potential of SARS-CoV-2. However, no studies were conducted to explore the existence of the micro-structural changes in the central nervous system after infection. We [...]

Authors: Tobin MJ, Laghi F, Jubran A PMID: 32539537 PMCID: PMC7397783 DOI: 10.1164/rccm.202006-2157CP Abstract Patients with coronavirus disease (COVID-19) are described as exhibiting oxygen levels incompatible with life without dyspnea. The pairing-dubbed happy hypoxia but more precisely termed silent hypoxemia-is especially bewildering to physicians and is considered as defying basic biology. This combination has attracted [...]

Authors: Hiedra R, Lo KB, Elbashabsheh M, Gul F, Wright RM PMID: 32662690 PMCID: PMC7441798 DOI: 10.1080/14787210.2020.1794819 Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic has affected almost 2.5 million people worldwide with almost 170,000 deaths reported to date. So far, there is scarce evidence for the current treatment options available for COVID-19. Vitamin C [...]

Authors: Qin C, Zhou L, Hu Z, Zhang S PMID: 32161940 PMCID: PMC7108125 DOI: 10.1093/cid/ciaa248 Abstract Background: In December 2019, coronavirus 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China. Methods: Demographic and clinical data of all confirmed cases with COVID-19 on admission at Tongji Hospital from 10 January to 12 February 2020 were [...]