Authors: Brown R, Sam CH, Gxreen T, Wood S PMID: 25144853 DOI: 10.3109/19390211.2014.950783 Abstract Chewing gum alleviates symptoms of gastro-esophageal reflux (GER) following a refluxogenic meal. GutsyGum(tm), a chewing gum developed to alleviate the symptoms of GER contains calcium carbonate, with a proprietary blend of licorice extract, papain, and apple cider vinegar (GiGs®). The efficacy [...]

Authors: Dabbagh-Bazarbachi H, Clergeaud G, Quesada IM, Ortiz M, O'Sullivan CK PMID: 25050823 DOI: 10.1021/jf5014633 Abstract Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and metabolic pathways. Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act [...]

Authors: Hine C, Mitchell JR PMID: 24905161 PMCID: PMC4278638 DOI: 10.1016/j.stem.2014.05.016 Abstract Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic [...]

Authors: Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS PMID: 24905167 PMCID: PMC4102383 DOI: 10.1016/j.stem.2014.04.014 Abstract Immune system defects are at the center of aging and a range of diseases. Here, we show that prolonged fasting reduces circulating IGF-1 levels and PKA activity in various cell populations, leading to signal [...]

Authors: Valentova K, Vrba J, Bancirova M, Ulrichova J. PMID: 24680690 DOI: 10.1016/j.fct.2014.03.018 Abstract The flavonoid isoquercitrin (quercetin-3-O-β-d-glucopyranoside) is commonly found in medicinal herbs, fruits, vegetables and plant-derived foods and beverages. This article reviews the occurrence, preparation, bioavailability, pharmacokinetics, toxicology and biological activity of isoquercitrin and "enzymatically modified (α-glucosylated) isoquercitrin" (EMIQ). Pure isoquercitrin can now [...]

Authors: Mooventhan A, Nivethitha L PMID: 24926444 PMCID: PMC4049052 DOI: 10.4103/1947-2714.132935 Abstract The use of water for various treatments (hydrotherapy) is probably as old as mankind. Hydrotherapy is one of the basic methods of treatment widely used in the system of natural medicine, which is also called as water therapy, aquatic therapy, pool therapy, and [...]

Authors: Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC et al. PMID: 24821822 PMCID: PMC4041680 DOI: 10.1634/theoncologist.2014-0086 Abstract Background: Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients [...]

Authors: Pietrocola F, Malik SA, Marino G, Vacchelli E, Senovilla L, Chaba K et al. PMID: 24769862 PMCID: PMC4111762 DOI: 10.4161/cc.28929 Abstract Epidemiological studies and clinical trials revealed that chronic consumption coffee is associated with the inhibition of several metabolic diseases as well as reduction in overall and cause-specific mortality. We show that both natural [...]

Authors: Sinha RA, Farah BL, Singh BK, Siddique MM, Li Y, Wu Y et al. PMID: 23929677 DOI: 10.1002/hep.26667 Abstract Caffeine is one of the world's most consumed drugs. Recently, several studies showed that its consumption is associated with lower risk for nonalcoholic fatty liver disease (NAFLD), an obesity-related condition that recently has become the [...]

Authors: Younger J, Parkitny L, McLain D PMID: 24526250 PMCID: PMC3962576 DOI: 10.1007/s10067-014-2517-2 Abstract Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn's disease, multiple sclerosis, and complex regional pain syndrome. We review the evidence that LDN may operate as a novel anti-inflammatory agent in the central nervous [...]