Authors: Houghton CA, Fassett RG, Coombes JS PMID: 24147970 DOI: 10.1111/nure.12060 Abstract Cruciferous vegetables are widely acknowledged to provide chemopreventive benefits in humans, but they are not generally consumed at levels that effect significant change in biomarkers of health. Because consumers have embraced the notion that dietary supplements may prevent disease, this review considers whether [...]

Authors: Ray K PMID: 23982685 DOI: 10.1038/nrgastro.2013.170 Abstract Coffee drinking is a global phenomenon, with an estimated >2.25 billion cups of coffee consumed in the world every day. A myriad of health benefits across a wide range of diseases have been attributed to coffee consumption and much research has focussed on the effects of caffeine [...]

Authors: Ranjbar E, Kasaei MS, Mohammad-Shirazi M, Shams J, Mostafavi SA PMID: 24130605 PMCID: PMC3796297 Abstract Objective: Major depression is a mood disorder that causes changes in physical activity, appetite, sleep and weight. Regarding the role of zinc in the pathology of depression, the present study was aimed to investigate the effects of zinc supplementation [...]

Authors: Kessler NJ, Hong J PMID: 24139013 DOI: 10.1016/j.jbmt.2013.03.001 Abstract The unsatisfactory results associated with conventional treatments for symptoms of diabetic peripheral neuropathy (DPN) demonstrate a need for research into alternative therapies. The purpose of this study was to determine the efficacy of whole body vibration therapy (WBV) as a treatment for pain associated with [...]

Authors: LaRocca TJ, Gioscia-Ryan RA, Hearon CM, Seals DR PMID: 23612189 PMCID: PMC3700669 DOI: 10.1016/j.mad.2013.04.004 Abstract Arterial aging, characterized by stiffening of large elastic arteries and the development of arterial endothelial dysfunction, increases cardiovascular disease (CVD) risk. We tested the hypothesis that spermidine, a nutrient associated with the anti-aging process autophagy, [...]

Authors: Renoir T PMID: 23596418 PMCID: PMC3627130 DOI: 10.3389/fphar.2013.00045 Abstract Besides demonstrated efficacy, selective serotonin reuptake inhibitors (SSRIs) hold other advantages over earlier antidepressants such as greater tolerability and a wider range of clinical applications. However, there is a growing body of clinical evidence which suggests that SSRIs could, in some cases, be associated with [...]

Authors: Nowotarski SL, Woster PM, Casero RA PMID: 23432971 PMCID: PMC4027058 DOI: 10.1017/erm.2013.3 Abstract Polyamines are small organic cations that are essential for normal cell growth and development in eukaryotes. Under normal physiological conditions, intracellular polyamine concentrations are tightly regulated through a dynamic network of biosynthetic and catabolic enzymes, and a poorly characterised transport system. [...]

Authors: Lee MR, Wehring HJ, McMahon RP, Cascella N, Liu F, Bellack A et al. PMID: 23415472 PMCID: PMC4125132 DOI: 10.1016/j.schres.2013.01.001 Abstract Background: Deficits in olfactory identification have been widely reported in patients with schizophrenia (SZ) and are associated with negative symptomatology. Adjunctive oxytocin delivered intranasally has been shown to improve some aspects of social [...]

Authors: Usami O, Saitoh H, Ashino Y, Hattori T PMID: 23337623 DOI: 10.1620/tjem.229.137 Abstract Acyclovir is known for its antiviral activity against some pathogenic viruses such as the Epstein-Barr virus (EBV) that causes infectious mononucleosis (IM) and IM-like illness. Therefore, we empirically administered acyclovir to patients with suspected EBV-IM and IM like-illness, upon their admission [...]

Authors: Minois N, Bauer MA, Rockenfeller P, Eisneber T, Brandhorst S, Kroemer G PMID: 23059820 PMCID: PMC3481127 doi: 10.1038/cddis.2012.139 Abstract The naturally occurring polyamine spermidine (Spd) has recently been shown to promote longevity across species in an autophagy-dependent manner. Here, we demonstrate that Spd improves both survival and locomotor activity of the fruit fly Drosophila [...]