Authors: Goldhamer AC, Klaper M, Foorohar A, Myers TR PMID: 26655228 PMCID: PMC4680557 DOI: 10.1136/bcr-2015-211582 Abstract Follicular lymphoma (FL), the second most common non-Hodgkin's lymphoma (NHL), is well characterised by a classic histological appearance and an indolent course. Current treatment protocols for FL range from close observation to immunotherapy, chemotherapy and/or radiotherapies. We report the [...]

Authors: Panahi Y, Khedmat H, Valizadegan G, Mohtashami R, Sahebkar A PMID: 26742306 DOI: 10.1016/s0254-6272(15)30151-5 Abstract Objective: To investigate the use of Aloe vera (A. vera) for the treatment of gastroesophageal reflux disease (GERD) symptoms and compare its effects with those of omeprazole and ranitidine. Methods: In this pilot, randomized controlled trial, 79 subjects were [...]

Authors: Khandouzi N, Shidfar F, Rajab A, Rahideh T, Hosseini P, Taheri MM PMID: 25561919 PMCID: PMC4277626 Abstract Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Anti-diabetic, hypolipidemic and anti-oxidative properties of ginger have been noticed in several researches. The present study [...]

Authors: McClure D, Greenman SC, Koppulu SS, Varvara M, Yaseen ZS, Galynker II PMID: 26414234 PMCID: PMC4892785 DOI: 10.1097/NMD.0000000000000378 Abstract This double-blind, sham-controlled study sought to investigate the effectiveness of cranial electrotherapy stimulation (CES) for the treatment of bipolar II depression (BD II). After randomization, the active group participants (n = 7) received 2 mA [...]

Authors: Langguth B PMID: 26261868 DOI: 10.1097/MOO.0000000000000185 Abstract Purpose of review: Tinnitus, the perception of sound in the absence of a corresponding external acoustic stimulus, is a highly prevalent and frequently severely impairing disorder with worldwide impact. In this article after a short overview about epidemiology and pathophysiology the currently available treatment options will be [...]

Abstract How on earth could an antidepressant drug drive someone to murder? In the past two columns RxISK has heard from two people who know they can. In The Man Who Thought He Was A Monster, Steindor Erlingsson shared his own story of being tormented with urges to stab his wife and young children while [...]

Schmitt B, Vicenzi M, Garrel C, Denis FM. PMID: 26262996 PMCID: PMC4536296 DOI: 10.1016/j.redox.2015.07.012 Abstract Glutathione (GSH) is critical to fight against oxidative stress. Its very low bioavailability limits the interest of a supplementation. The purpose of this study was to compare the bioavailability, the effect on oxidative stress markers and the safety of [...]

Authors: Akagawa M, Nakano M, Ikemoto K PMID: 26168402 DOI: 10.1080/09168451.2015.1062715 Abstract Pyrroloquinoline quinone (PQQ), an aromatic tricyclic o-quinone, was identified initially as a redox cofactor for bacterial dehydrogenases. Although PQQ is not biosynthesized in mammals, trace amounts of PQQ have been found in human and rat tissues because of its wide distribution in dietary [...]

Authors: Serhan CN PMID: 24899309 PMCID: PMC4263681 doi: 10.1038/nature13479 Abstract Advances on mechanisms in resolution of acute inflammation uncovered a new genus of pro-resolving lipid mediators that include separate families of molecules: lipoxins, resolvins, protectins and maresins, collectively coined specialized pro-resolving mediators (SPM). Synthetic SPM possess potent bioactions when administered in vivo. In animal experiments, [...]

Authors: Weng Z, Patel AB, Panagiotidou S, Theoharides TC PMID: 25498791 PMCID: PMC4388775 DOI: 10.1016/j.jaci.2014.10.032 Abstract Background: Mast cells (MCs) are hematopoietic cells that mature in tissues and are involved in allergy, immunity, and inflammation by secreting multiple mediators. The natural flavone luteolin has anti-inflammatory actions and inhibits human mast cells (MCs). Objective: We sought [...]