Authors: Levine TD, Kafaie J, Zeidman LA, Saperstein DS, Bland RJ PMID: 31650561 DOI: 10.1002/mus.26748 Abstract Introduction: Causes of small-fiber peripheral neuropathies (SFN) are often undefined. In this study we investigated associations of serum autoantibodies, immunoglobulin G (IgG) vs fibroblast growth factor receptor-3 (FGFR-3), and immunoglobulin M (IgM) vs trisulfated heparan disaccharide (TS-HDS) in cryptogenic [...]

Authors: Verbeke R, Lentacker I, Smedt SC, DeWitte H DOI:10.1016/j.nantod.2019.100766 Abstract In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool for vaccination. In the following decades, an improved understanding of the mRNA pharmacology, together with novel insights in immunology have positioned mRNA-based technologies as next-generation vaccines. This [...]

Authors: Kunnumakkara AB, Harsha C, Banik K, Vikkurthi R, Sailo BL, Bordoloi D PMID: 31361978 DOI: 10.1080/17425255.2019.1650914 Abstract Introduction: Since ancient times, turmeric has been used in several folklore remedies against various ailments. The principal component of turmeric is curcumin and its efficacy has been advocated in various in vitro, in vivo and clinical studies [...]

Authors: Amaravadi RK, Kimmelman AC, Debnath J PMID: 31434711 PMCID: PMC7306856 DOI: 10.1158/2159-8290.CD-19-0292 Abstract Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and metabolic adaptation, has been implicated as a process that regulates cancer. Although autophagy induction may limit the development of tumors, evidence in mouse models demonstrates that autophagy inhibition can limit [...]

Authors: Matsushita H, Latt HM, Koga Y, Nishiki T, Matsui H PMID: 31400490 DOI: 10.1016/j.neuroscience.2019.07.046 Abstract Clinical reports show that oxytocin (OT) is related to stress-related disorders such as depression, anxiety disorder, and post-traumatic stress disorder. Two key structures in the brain should be paid special attention with regard to stress regulation, namely, the hypothalamus [...]

Authors: Morishita H, Mizushima N PMID: 31283377 DOI: 10.1146/annurev-cellbio-100818-125300 Abstract Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular [...]

Authors: Mohamed M, Lila AS, Shimizu T, Alaaeldin E, Hussein A, Sarhan HA et al. PMID: 31275462 PMCID: PMC6598536 DOI: 10.1080/14686996.2019.1627174 Abstract A commonly held view is that nanocarriers conjugated to polyethylene glycol (PEG) are non-immunogenic. However, many studies have reported that unexpected immune responses have occurred against PEG-conjugated nanocarriers. One unanticipated response is the [...]

Authors: Hengartner MP, Ploderi M PMID: 31234169 DOI: 10.1159/000501215 Abstract Studies disagree whether antidepressants may trigger suicide attempts in adults with major depression. Some meta-analyses of randomized controlled trials (RCT) found significantly elevated rates of (attempted) suicide in antidepressant arms relative to placebo, whereas others did not. A recent study by Khan et al. likewise [...]

Riva A, Ronchi M, Petrangolini G, Bosisio S, Allegrini P. PMID: 30328058 PMCID: PMC6418071 DOI: 10.1007/s13318-018-0517-3 Abstract Background and objectives: The importance of quercetin and flavonoids in the diet and as food supplements is well known, and literature studies support their potential use to treat several human diseases. Many beneficial properties have been described [...]

Authors: Theoharides TC, Tsilioni I, Ren H PMID: 30884251 PMCID: PMC7003574 DOI: 10.1080/1744666X.2019.1596800 Abstract An increasing number of patients present with multiple symptoms affecting many organs including the brain due to multiple mediators released by mast cells. These unique tissue immune cells are critical for allergic reactions triggered by immunoglobulin E (IgE), but are also [...]