Authors: Teng M, Zhao YJ, Khoo AL, Yeo TC, Yong QW, Lim BP PMID: 31769848 DOI: 10.1093/nutrit/nuz074 Abstract Context: Coconut oil is rich in medium-chain fatty acids and has been claimed to have numerous health benefits. Objective: This review aimed to examine the evidence surrounding coconut oil consumption and its impact on cardiovascular health. Data [...]

Authors: Colunga Biancatelli RM, Berrill M, Mohammed YH, Marik PE PMID: 32148926 PMCID: PMC7024751 DOI: 10.21037/jtd.2019.12.85 Abstract Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO), and despite decades of research, novel initiatives are drastically needed. According to the current literature, oxidative imbalance and mitochondrial dysfunction are common features of [...]

Authors: Moballegh Nasery M, Abadi B, Poormoghadam D, Zarrabi A, Keyhanvar P, Tavakol S et al. PMID: PMC7037405 DOI: 10.3390/molecules25030689 Abstract Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are currently being utilized in the prevention and treatment of various chronic diseases such [...]

Authors: Nicolas P, Maia MF, Bassat Q, Kobylinski KC, Monteiro W Abstract Background About 3·7 billion doses of ivermectin have been distributed in mass drug administration (MDA) campaigns globally over the past 30 years. At 10–100 times higher than current human doses, ivermectin is a known teratogen in mammals. During these campaigns with recommended [...]

Authors: deCabo R, Mattson MP PMID: 31881139 DOI: 10.1056/NEJMra1905136 Abstract Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity. Keywords: fasting, intermittent fasting, health [...]

Authors: Colunga Biancatelli RM, Berrill M, Marik PE PMID: 31852327 DOI: 10.1080/14787210.2020.1706483 Abstract There is a growing interest in the administration of vitamin C beyond the treatment of hypovitaminosis C in malnourished patients. This has been driven by a 2016 ‘before-after’ study which suggested a substantial survival benefit from a protocol that included hydrocortisone, ascorbic [...]

Authors: Liu J, Liang H, Chen C, Wang X, Qu F, Wang H PMID: 31755894 PMCID: PMC6900471 DOI: 10.1042/BSR20192489 Abstract Glioma is one of the most common types of primary brain tumors. Ivermectin (IVM), a broad-spectrum antiparasitic drug, has been identified as a novel anticancer agent due to its inhibitory effects on the proliferation of [...]

Authors: de Moreuil C, Alavi Z, Pasquier E PMID: 31633823 PMCID: PMC6983516 DOI: 10.1111/bcp.14131 Abstract Recurrent miscarriage (RM) and vasculoplacental disorders, such as preeclampsia (PE), affect women of childbearing age worldwide. Vascular endothelial dysfunction and immunological impairment are associated with both RM and PE. To date, there is no effective or optimal therapeutic approach for [...]

Authors: Shukla AM, Shukla AW PMID: 31844421 PMCID: PMC6905642 DOI: 10.7573/dic.2019-9-1 Abstract Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney [...]

Authors: Santos HO, Howell S, Earnest CP, Teixeira FJ PMID: 31707063 DOI: 10.1016/j.pcad.2019.11.001 Abstract In recent years, health professionals and laypersons have disseminated misinformation regarding the consumption of coconut oil. Those encouraging the supplementation of coconut oil argue that it provides health benefits and protective cardiovascular effects. Our article examines the effects of coconut oil [...]