Authors: Stoehr JR, Choi JN, Colavincenzo M, Vanderweil S PMID: 30604379 DOI: 10.1007/s40257-018-0409-y Abstract Topical minoxidil is a well-known and often-utilized drug in dermatological practice for the treatment of alopecia. It was approved by the United States Food and Drug Administration for the treatment of androgenetic alopecia in 1988. Since its approval, minoxidil has been [...]

Authors: Finisguerra A, Borgatti R, Urgesi C PMID: 30787895 PMCID: PMC6373438 DOI: 10.3389/fpsyg.2019.00135 Abstract In the last years, there has been a growing interest in the application of different non-invasive brain stimulation techniques to induce neuroplasticity and to modulate cognition and behavior in adults. Very recently, different attempts have been made to induce functional plastic [...]

Authors: Beckman JA PMID: 30560579 PMCID: PMC6516871 doi: 10.1002/14651858.CD004437.pub5 AbstractBackgroundThrombolytic therapy is usually reserved for patients with clinically serious or massive pulmonary embolism (PE). Evidence suggests that thrombolytic agents may dissolve blood clots more rapidly than heparin and may reduce the death rate associated with PE. However, there are still concerns about the possible risk [...]

Authors: Sabel BA, Flammer J, Merabet LB PMID: 30412515 PMCID: PMC6294586 DOI: 10.3233/RNN-180880 Abstract Vision loss due to ocular diseases such as glaucoma, optic neuropathy, macular degeneration, or diabetic retinopathy, are generally considered an exclusive affair of the retina and/or optic nerve. However, the brain, through multiple indirect influences, has also a major impact on [...]

Authors: Marik PE PMID: 30441816 doi: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid [...]

Authors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 doi: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]

Authors: Brononi AR, Sampaio-Junior B, Moffa AH, Aparicio L, Gordon P, Klein I et al. PMID: 30328957 PMCID: PMC6781710 DOI: 10.1590/1516-4446-2017-0018 Abstract Objective: Noninvasive brain stimulation (NIBS) techniques, such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), are increasingly being used to treat mental disorders, particularly major depression. The aim of [...]

Authors: Hadanny A, Abbott S, Suzin G, Bechor Y, Efrati S PMID: 30269074 PMCID: PMC6169752 DOI: 10.1136/bmjopen-2018-023387 Abstract Objectives: The aim of the study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) in participants suffering from chronic neurological deficits due to traumatic brain injury (TBI) of all severities in [...]

Authors: Toljan K, Vrooman B PMID: 30248938 PMCID: PMC6313374 DOI: 10.3390/medsci6040082 Abstract Naltrexone and naloxone are classical opioid antagonists. In substantially lower than standard doses, they exert different pharmacodynamics. Low-dose naltrexone (LDN), considered in a daily dose of 1 to 5 mg, has been shown to reduce glial inflammatory response by modulating Toll-like receptor 4 [...]

Authors: Plantone D, Koudriavtseva T PMID: 29737455 DOI: 10.1007/s40261-018-0656-y Abstract The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), [...]